Universität zu Köln

Manegold-Brauer, Gwendolin ORCID: 0000-0003-4292-6779, Berg, C., Floeck, A., Rueland, A., Gembruch, U. and Geipel, A. (2015). Uptake of non-invasive prenatal testing (NIPT) and impact on invasive procedures in a tertiary referral center. Arch. Gynecol. Obstet., 292 (3). S. 543 - 549. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

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Abstract

The introduction of non-invasive prenatal testing (NIPT) by isolation of cell-free fetal DNA from maternal blood is a new diagnostic option in prenatal care. The aim of the study was to investigate the algorithm of prenatal testing before and after the introduction of NIPT in a tertiary referral center and to investigate the influence of NIPT on the frequency of invasive procedures. Retrospective data analysis was conducted of all singleton pregnancies that presented for first trimester screening 17 months before and after the introduction of NIPT (n = 2271). Women were categorized into three risk groups: low risk for trisomy 21 (< 1:1000), intermediate risk (1:101-1:1000) and high risk (a parts per thousand yen1:100). The choice of diagnostic testing after FTS was analyzed. 1093 (group 1) presented before and 1178 (group 2) after the introduction of NIPT. The rate of high-risk patients was equal in both groups (14.4 vs. 15.4 %). No differences were found with regard to invasive testing (11.6 vs. 11.3 %). NIPT was chosen by 3.7 % (44/1178) in group 2. Of those with NIPT, 72.7 % had a risk estimate of < 1:100, but 90.9 % were a parts per thousand yen35 years old. The rate of NIPT among high-risk patients with a normal ultrasound examination was 25 %. At present, NIPT is chosen mainly for reassurance by patients not considered to be at high risk. In the high-risk group, NIPT can be offered if the ultrasound examination is normal and the risk is high due to maternal age or serum screening alone. The rate of invasive testing was not reduced in this selected population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Manegold-Brauer, Gwendolin UNSPECIFIED orcid.org/0000-0003-4292-6779 UNSPECIFIED Berg, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Floeck, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueland, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Geipel, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-394892
DOI:	10.1007/s00404-015-3674-5
Journal or Publication Title:	Arch. Gynecol. Obstet.
Volume:	292
Number:	3
Page Range:	S. 543 - 549
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-0711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-FREE DNA; FETAL DNA; ANEUPLOIDY; TRISOMY-21; DIAGNOSIS; WOMEN; POSITION; SOCIETY; RATES; CARE Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39489