Universität zu Köln

Zinzani, P. L., Sasse, S., Radford, J., Shonukan, O. and Bonthapally, V. (2015). Experience of brentuximab vedotin in relapsed/refractory Hodgkin lymphoma and relapsed/refractory systemic anaplastic large-cell lymphoma in the Named Patient Program: Review of the literature. Crit. Rev. Oncol./Hematol., 95 (3). S. 359 - 370. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-0461

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Abstract

Brentuximab vedotin was made available via a Named Patient Program (NPP) to non-US/Canadian patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) or systemic anaplastic large-cell lymphoma (sALCL) until approval in their respective countries. We re-evaluated the efficacy and safety NPP data in a pooled analysis. Through a systematic literature review, 21 NPP publications were identified describing 14 cohorts (N=245). Among patients with a specified diagnosis, 207 had HL, 28 had ALCL, and one had CD30+ T-cell lymphoma (not specified). In cohorts reporting response, overall response and complete remission rates were 67% and 26%, respectively, in R/R HL, and 75% and 74%, respectively, in R/R ALCL. Incidences of grade 3/4 neurologic and hematologic toxicities were 6% and 12%, respectively; 5% of patients discontinued because of toxicity. In real-world practice, response rates and tolerability to brentximab vedotin are similar to those reported in the two pivotal phase 2 trials in these settings. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zinzani, P. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sasse, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Radford, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shonukan, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonthapally, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395317
DOI:	10.1016/j.critrevonc.2015.03.011
Journal or Publication Title:	Crit. Rev. Oncol./Hematol.
Volume:	95
Number:	3
Page Range:	S. 359 - 370
Date:	2015
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-0461
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SGN-35; POTENT; TRANSPLANTATION Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39531