Universität zu Köln

Sagir, Abdurrahman, Glaubach, Birgit, Sahin, Kurtulus, Graf, Dirk, Erhardt, Andreas, Oette, Mark and Hauessinger, Dieter (2015). Transient Elastography for the Detection of Liver Damage in Patients with HIV. Infect. Dis. Ther., 4 (3). S. 355 - 365. LONDON: SPRINGER LONDON LTD. ISSN 2193-6382

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Abstract

Introduction: Highly active antiretroviral therapy (HAART) is effective and well tolerated, but hepatotoxicity is relatively common. Different non-invasive methods are available for detecting liver fibrosis in patients with chronic liver disease. Methods: Patients who were HIV positive and who had given their informed consent were included in this cross-sectional study. Transient elastography [FibroScan (R) (FS); Echosens], serum hyaluronic acid (HA), Hepascore (HS), Fibrosis-4 (FIB-4), and aspartate aminotransferase to platelet ratio index (APRI) were used to detect liver fibrosis in the patients. The agreement between FS and the other methods was evaluated. To observe the hepatotoxicity of HAART, patients with chronic viral hepatitis B or C were excluded by detection of hepatitis B surface antigens and hepatitis C virus antibodies. Patients with chronic alcohol intake were excluded by measuring carbohydrate-deficient transferrin (CDT). FS correlation with the duration of therapy with protease inhibitors (PI), nucleoside reverse transcriptase inhibitors (NRTI), and non-nucleoside reverse transcriptase inhibitors (NNRTI) was evaluated. Results: Overall, 203 patients were included in the study. The agreement between the different tests ranged from 64% to 77%: FS vs. HA, 72%; FS vs. APRI, 74%; FS vs. HS, 77%; and FS vs. FIB-4, 64%. After excluding patients with chronic hepatitis B or C and elevated CDT, 153 patients remained for studying the hepatotoxicity of HAART. A significant correlation of FS with the duration of medication intake was observed for PIs (P = 0.026; r = 0.18). NRTI and NNRTI therapy duration did not correlate with FS. Conclusions: The agreement between FS and other tests ranged from 64% to 77%. A significant correlation was found between liver stiffness and the duration of therapy with PIs, which underlines the known hepatotoxicity of this substance group.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sagir, Abdurrahman UNSPECIFIED UNSPECIFIED UNSPECIFIED Glaubach, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Sahin, Kurtulus UNSPECIFIED UNSPECIFIED UNSPECIFIED Graf, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Erhardt, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Oette, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauessinger, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395538
DOI:	10.1007/s40121-015-0073-y
Journal or Publication Title:	Infect. Dis. Ther.
Volume:	4
Number:	3
Page Range:	S. 355 - 365
Date:	2015
Publisher:	SPRINGER LONDON LTD
Place of Publication:	LONDON
ISSN:	2193-6382
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39553