Universität zu Köln

Schmutzler, Rita Katharina and Meindl, Alfons (2015). The first targeted therapy in ovarian cancer permitted for BRCA1/2 mutation carriers. Med. Genet., 27 (2). S. 228 - 231. NEW YORK: SPRINGER. ISSN 1863-5490

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Abstract

Olaparib (Lynparza (TM)) is an oral, small-molecule, poly (ADP-ribose) polymerase (PARP) inhibitor being developed by AstraZeneca for the treatment of solid tumours. The primary indication for which olaparib is being developed is BRCA1/2 mutation-positive ovarian cancer. A capsule formulation of the drug has received approval for use in this setting in the EU by the European Medicines Agency (EMA). The application of olaparib has been indicated for germline and somatic mutations in BRCA1 and/or BRCA2 in patients with platinum-sensitive recurrence of serous high-grade ovarian cancer. This requires the analysis of DNA isolated from fresh frozen paraffin-embedded (FFPE) material rather than DNA isolated from blood. However, this therapy-driven switch raises profound technical challenges and intriguing problems in medical care and counselling. For example, decreased sensitivity in mutation detection and a reduced possibility in the evaluation of the variant of unknown significance (VUS) may correlate with inadequate medical care of the patients and their families. Therefore, prospective studies, including the collection of genetic, histopathological and clinical data, are mandatory.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmutzler, Rita Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Meindl, Alfons UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-397365
DOI:	10.1007/s11825-015-0047-1
Journal or Publication Title:	Med. Genet.
Volume:	27
Number:	2
Page Range:	S. 228 - 231
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1863-5490
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39736