Universität zu Köln

Gloeckner, A. and Cornely, O. A. (2015). Candida glabrata - unique features and challenges in the clinical management of invasive infections. Mycoses, 58 (8). S. 445 - 451. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Candida glabrata is a pathogenic yeast with several unique biological features. This article provides an up-to-date review on current data and reasoning aspects of this clinically problematic organism. Haploidy, absence of pseudohyphae, facultative anaerobe growth of C.glabrata, as well as its intrinsically low susceptibility to azole antifungals require specific consideration in diagnosis and treatment approaches. As C.glabrata today represents a sizeable percentage of pathogens in candidaemia, the use of azole antifungals in upfront therapy of invasive yeast infections is discouraged by recent guidelines. While the selection of C.glabrata mutants with impaired susceptibility to echinocandins has been described, analyses of several clinical studies indicate an association of improved outcomes with the use of echinocandins as the primary treatment for invasive yeast infections with potential or documented involvement of C.glabrata.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gloeckner, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-397673
DOI:	10.1111/myc.12348
Journal or Publication Title:	Mycoses
Volume:	58
Number:	8
Page Range:	S. 445 - 451
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CRITICALLY-ILL PATIENTS; ANAEROBIC BLOOD CULTURE; AMPHOTERICIN-B; BREAKTHROUGH CANDIDEMIA; FUNGAL-INFECTIONS; ANTIFUNGAL AGENTS; RISK-FACTORS; FLUCONAZOLE; FUNGEMIA; SUSCEPTIBILITY Multiple languages Dermatology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39767