Universität zu Köln

Lagies, Ruth, Beck, Bodo B., Hoppe, Bernd, Sheta, Sahar S., Weiss, Verena, Sreeram, Narayanswami and ten Cate, Floris E. A. Udink (2015). Inhomogeneous Longitudinal Cardiac Rotation and Impaired Left Ventricular Longitudinal Strain in Children and Young Adults with End-Stage Renal Failure Undergoing Hemodialysis. Echocardiography-J. Cardiovasc. Ultrasound Allied Tech., 32 (8). S. 1250 - 1261. HOBOKEN: WILEY. ISSN 1540-8175

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Abstract

BackgroundCardiac dysfunction frequently complicates the clinical course of patients with end-stage renal failure (ESRF). Recently, we observed abnormal longitudinal cardiac rotation (LR) among patients with ESRF. In this study, we sought to quantify LR mechanics in patients undergoing hemodialysis (HD). MethodsTwenty-four subjects, 12 ESRF patients (58% male; age 17.54.4years) receiving HD, and 12 aged-matched controls, were prospectively studied. Patients underwent echocardiographic studies before and after HD. LR mechanics were quantified with two-dimensional speckle tracking echocardiography. Peak systolic left ventricular (LV) longitudinal strain and displacement measurements were obtained in all subjects. ResultsLR mechanics were successfully quantified in all subjects using 5 key echocardiographic features of LR. We identified two different inhomogeneous LR motion patterns in 41.7% of ESRF patients, characterized by a delayed timing of LR or increased segmental apical rotation. Inhomogeneous LR patterns were not found in controls. Timing of early-systolic counterclockwise LR increased after HD (P=0.006). In patients, late-systolic clockwise LR occurred earlier (P=0.043), and showed a significant prolongation after HD (P=0.003). Longitudinal strain was significantly impaired in patients (P=0.015), and further decreased after HD (P<0.0001). Strong correlations were observed between strain and displacement parameters and LR mechanics. ConclusionsQuantifying LR using speckle tracking echocardiography was feasible, easy, and reproducible. Inhomogeneous LR motion patterns were demonstrated in a large proportion of patients with ESRF. LV dysfunction seems the most important determinant of inhomogeneous LR. Further studies are required to validate these findings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lagies, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Beck, Bodo B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheta, Sahar S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Sreeram, Narayanswami UNSPECIFIED UNSPECIFIED UNSPECIFIED ten Cate, Floris E. A. Udink UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-397725
DOI:	10.1111/echo.12842
Journal or Publication Title:	Echocardiography-J. Cardiovasc. Ultrasound Allied Tech.
Volume:	32
Number:	8
Page Range:	S. 1250 - 1261
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1540-8175
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SPECKLE TRACKING ECHOCARDIOGRAPHY; MECHANICAL DYSSYNCHRONY; PEDIATRIC-PATIENTS; DISEASE; MOTION; HEART; HYPERTROPHY; MYOCARDIUM; DIALYSIS; IMPACT Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39772