Universität zu Köln

Schmidt, Manuela, Gutknecht, Danny, Simon, Jan C., Schulz, Jan-Niklas ORCID: 0000-0001-9286-206X, Eckes, Beate, Anderegg, Ulf and Saalbach, Anja (2015). Controlling the Balance of Fibroblast Proliferation and Differentiation: Impact of Thy-1. J. Invest. Dermatol., 135 (7). S. 1893 - 1903. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1523-1747

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Abstract

Fibroblasts provide matrix and regulatory mediators to the microenvironment and thereby contribute to maintenance of tissue homeostasis, wound healing, and tumor progression. In the present study, we addressed the functional relevance of Thy-1 for fibroblast functions in vitro and in vivo. Using fibroblasts from Thy-1(-/-) and wild-type mice, recombinant expression of Thy-1, and analysis of the interaction of fibroblasts with immobilized Thy-1, we showed that Thy-1 has a crucial role in the control of cell growth by suppressing proliferation and promoting apoptosis and differentiation of dermal fibroblasts. Function-blocking studies revealed that Thy-1 mediates the control of apoptosis and proliferation via modulation of beta 3 integrin function. Interestingly, Thy-1-mediated growth control appears to be a more general mechanism because it also regulates growth of tumor cells of different origin dependent on their beta 3 integrin expression. In summary, our findings point to an important role of Thy-1 in controlling the balance between proliferation and differentiation in dermal fibroblasts.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Manuela UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutknecht, Danny UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Jan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Jan-Niklas UNSPECIFIED orcid.org/0000-0001-9286-206X UNSPECIFIED Eckes, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Anderegg, Ulf UNSPECIFIED UNSPECIFIED UNSPECIFIED Saalbach, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-400064
DOI:	10.1038/jid.2015.86
Journal or Publication Title:	J. Invest. Dermatol.
Volume:	135
Number:	7
Page Range:	S. 1893 - 1903
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1523-1747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATED ENDOTHELIAL-CELLS; GROWTH-FACTOR-BETA; GRANULATION-TISSUE; LUNG FIBROBLASTS; GENE-EXPRESSION; MELANOMA-CELLS; INTEGRIN; MYOFIBROBLASTS; SUBPOPULATIONS; REGULATOR Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40006