Keyver-Paik, M. -D., Abramian, A., Maass, N. and Kuhn, W. (2015). Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in ovarian cancer. Importance and current trials. Gynakologe, 48 (7). S. 549 - 553. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0393

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Abstract

Background. Although ovarian cancer is usually limited to intraperitoneal dissemination for a long time and is basically sensitive to chemotherapy the majority of patients with ovarian cancer (> 70%) will not survive the first 5 years following diagnosis. The concept and effectiveness of using a local chemotherapy on the peritoneum has been conclusively and suficciently proven by the data on intraperitoneal postoperative chemotherapy. Since adjuvant, repeated intraperitoneal chemotherapy is associated with significant rates of complication and correlated discontinuation of treatment, a one-time hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) could be considered a possible alternative. Current situation and objectives. The data on treatment of patients using HIPEC are essentially limited to small case control studies and open trials on HIPEC in Germany are not yet available. In Germany more than 25 gynecological and surgical centers regularly perform HIPEC in patients with ovarian cancer. At the same time there are still no high evidential phase III trial data on the use of HIPEC in patients with ovarian cancer. Conclusion. The number of patients in Germany treated with HIPEC outside of clinical studies is increasing and treatment is carried out in many German and international centers in a non-standardized form. Therefore, prospective clinical trials on the use of HIPEC under standardized and controlled conditions are urgently needed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Keyver-Paik, M. -D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abramian, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maass, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhn, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-400360
DOI: 10.1007/s00129-015-3737-5
Journal or Publication Title: Gynakologe
Volume: 48
Number: 7
Page Range: S. 549 - 553
Date: 2015
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1433-0393
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Obstetrics & GynecologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40036

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