Petrelli, A., Kaesberg, S., Barbe, M. T., Timmermann, L., Rosen, J. B., Fink, G. R., Kessler, J. and Kalbe, E. (2015). Cognitive training in Parkinson's disease reduces cognitive decline in the long term. Eur. J. Neurol., 22 (4). S. 640 - 648. HOBOKEN: WILEY. ISSN 1468-1331

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Abstract

Background and purposePatients with Parkinson's disease (PD) are at high risk for cognitive dysfunction. Non-pharmacological interventions have attracted increasing interest for enhancing PD patients' cognitive functions. MethodsOne-year follow-up data (T-2) of a randomized controlled trial evaluating two 6-week cognitive trainings - a structured (NEUROvitalis, NV) and an unstructured (mentally fit, MF) program - compared with a waiting list control group (CG) in non-demented PD patients (Hoehn and Yahr I-III) are presented. Forty-seven PD patients were examined at T-2. Effects on overall cognitive functions (Mini-Mental State Examination and DemTect) were compared between all groups with repeated measurement analyses of variance. A combined score of the percentage change value from baseline (T-0) to T-2 was calculated to identify patients who retained or improved their cognitive state (responders). The risk of developing mild cognitive impairment (MCI) was analyzed. ResultsSignificant time x treatment effects on overall cognitive functions were found for both training groups, each compared separately to the CG (DemTect, P<0.05). Nine patients (56.3%) of the NV group, seven (41.2%) of the MF group and three (21.4%) of the CG were responders. Comparing NV to CG the odds ratio was 4.7 [95% confidence interval (0.8; 33.3)], and comparing MF to CG it was 2.6 [95% confidence interval (0.4; 17.4)]. MCI risk for patients without prior MCI was 40.0% in CG, 18.2% in MF and 18.2% in NV. The odds ratio was 3 comparing NV to CG, MF to CG. DiscussionThis study gives evidence that cognitive training may be effective to prevent cognitive decline and onset of MCI in PD patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Petrelli, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaesberg, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, M. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosen, J. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, G. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessler, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-404065
DOI: 10.1111/ene.12621
Journal or Publication Title: Eur. J. Neurol.
Volume: 22
Number: 4
Page Range: S. 640 - 648
Date: 2015
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1468-1331
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IMPAIRMENT; DEMENTIA; EFFICACY; LIFEMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40406

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