Demir, M., Nigemeier, J., Kuetting, F., Bowe, A., Schramm, C., Hoffmann, V., Waldschmidt, D., Goeser, T. and Steffen, H-M. (2015). Clinical management of chronic hepatitis B infection: results from a registry at a German tertiary referral center. Infection, 43 (2). S. 153 - 163. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

Full text not available from this repository.

Abstract

We studied a cohort of adult patients with chronic hepatitis B (CHB) infection, followed at a tertiary referral liver center in Germany over 12.5 years to analyze the clinical features and impact of management on disease progression and survival of CHB patients in general and of those with CHB and HCC in particular. We retrospectively evaluated the medical records of 242 adult (age a parts per thousand yen 18 years) patients. CHB was defined as positive hepatitis B surface antigen (HBsAg) and/or HBV-DNA levels > 10 IU/mL for at least 6 months. Patient demographics, HBV markers, antiviral treatment, laboratory parameters, liver imaging and histology were recorded for each visit. HCC patients were divided into two groups and separately analyzed (group 1: n = 24, HCC at first visit and group 2: n = 11, HCC during surveillance). The mean age was 44 years in CHB patients without HCC (63 % male) and about 59 years in patients with HCC (77 % male). Antiviral therapy was given to 59 % of patients without HCC compared to only 25 % in group 1 and 18 % in group 2 with comparable median HBV DNA levels of approximately 36,000 IU/mL. There was no statistically significant difference concerning the HCC stages (Milan, UCSF, BCLC) at first diagnosis. Five-year survival was 19 % in group 1 vs. 64 % in group 2 (p = 0.019), with LTx performed in 12 vs. 45 %, respectively. Surveillance of CHB patients did not result in early stage detection of HCC but in a higher likelihood to receive potentially curative treatments.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Demir, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nigemeier, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuetting, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bowe, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schramm, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waldschmidt, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goeser, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steffen, H-M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-408272
DOI: 10.1007/s15010-015-0751-4
Journal or Publication Title: Infection
Volume: 43
Number: 2
Page Range: S. 153 - 163
Date: 2015
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1439-0973
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEPATOCELLULAR-CARCINOMA; LIVER-TRANSPLANTATION; CIRRHOTIC-PATIENTS; VIRUS; DIAGNOSIS; THERAPY; RISK; RECOMMENDATIONS; EPIDEMIOLOGY; PREVENTIONMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40827

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item