Polidori, M. C., Ruggiero, C., Croce, M. F., Raichi, T., Mangialasche, F., Cecchetti, R., Pelini, L., Paolacci, L., Ercolani, S. and Mecocci, P. (2015). Association of increased carotid intima-media thickness and lower plasma levels of vitamin C and vitamin E in old age subjects: implications for Alzheimer's disease. J. Neural Transm., 122 (4). S. 523 - 531. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

In light of the recent advances regarding the role of vascularity in Alzheimer's disease (AD) pathophysiology, the relationship between plasma levels and activities of the major antioxidant molecules and the carotid intima-media thickness (C-IMT) of older persons with no or very mild cognitive impairment was evaluated. The underlying hypothesis is that the IMT may be an indirect index of vascular damage in persons with low levels of plasma antioxidants. Plasma levels of vitamins A, C, E, of uric acid as well as activities of the plasma antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured. Plasma levels of vitamins C and E significantly decreased among participants from the first to the fourth IMT quartile, with a linear slope only for vitamin C. Compared to participants in the lowest vitamin C quartile, the probability to have IMT > 1.2 mm significantly decreased among persons from the second to the fourth quartile independent of confounders. In conclusion, only vitamin C plasma levels appear to be selectively associated with the risk of increasing C-IMT. An adequate vitamin C status might be particularly important for protection against AD and other clinical manifestations of vascular and cognitive ageing.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Polidori, M. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruggiero, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Croce, M. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raichi, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mangialasche, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cecchetti, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pelini, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paolacci, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ercolani, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mecocci, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-409121
DOI: 10.1007/s00702-014-1357-1
Journal or Publication Title: J. Neural Transm.
Volume: 122
Number: 4
Page Range: S. 523 - 531
Date: 2015
Publisher: SPRINGER WIEN
Place of Publication: WIEN
ISSN: 1435-1463
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CORONARY-HEART-DISEASE; ASCORBIC-ACID; RISK-FACTORS; ANTIOXIDANT STATUS; COGNITIVE DECLINE; EUROPEAN-SOCIETY; TASK-FORCE; DEMENTIA; ATHEROSCLEROSIS; MORTALITYMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40912

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