Universität zu Köln

Horikawa, Makoto ORCID: 0000-0002-5094-7070, Sural, Surojit ORCID: 0000-0002-0422-9799, Hsu, Ao-Lin ORCID: 0000-0002-2864-3134 and Antebi, Adam (2015). Co-chaperone p23 Regulates C. elegans Lifespan in Response to Temperature. PLoS Genet., 11 (4). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7404

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Abstract

Temperature potently modulates various physiologic processes including organismal motility, growth rate, reproduction, and ageing. In ectotherms, longevity varies inversely with temperature, with animals living shorter at higher temperatures. Thermal effects on lifespan and other processes are ascribed to passive changes in metabolic rate, but recent evidence also suggests a regulated process. Here, we demonstrate that in response to temperature, daf-41/ZC395.10, the C. elegans homolog of p23 co-chaperone/prostaglandin E synthase-3, governs entry into the long-lived dauer diapause and regulates adult lifespan. daf-41 deletion triggers constitutive entry into the dauer diapause at elevated temperature dependent on neurosensory machinery (daf-10/IFT122), insulin/IGF-1 signaling (daf-16/FOXO), and steroidal signaling (daf-12/FXR). Surprisingly, daf-41 mutation alters the longevity response to temperature, living longer than wild-type at 25 degrees C but shorter than wild-type at 15 degrees C. Longevity phenotypes at 25 degrees C work through daf-16/FOXO and heat shock factor hsf-1, while short lived phenotypes converge on daf-16/FOXO and depend on the daf-12/FXR steroid receptor. Correlatively daf-41 affected expression of DAF-16 and HSF-1 target genes at high temperature, and nuclear extracts from daf-41 animals showed increased occupancy of the heat shock response element. Our studies suggest that daf-41/p23 modulates key transcriptional changes in longevity pathways in response to temperature.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Horikawa, Makoto UNSPECIFIED orcid.org/0000-0002-5094-7070 UNSPECIFIED Sural, Surojit UNSPECIFIED orcid.org/0000-0002-0422-9799 UNSPECIFIED Hsu, Ao-Lin UNSPECIFIED orcid.org/0000-0002-2864-3134 UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-409342
DOI:	10.1371/journal.pgen.1005023
Journal or Publication Title:	PLoS Genet.
Volume:	11
Number:	4
Date:	2015
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1553-7404
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEAT-SHOCK-FACTOR; CAENORHABDITIS-ELEGANS; DAUER FORMATION; MOLECULAR CHAPERONES; THERMOSENSORY NEURONS; TGF-BETA; PROTEIN; HSP90; LONGEVITY; RECEPTOR Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40934