Leuchte, H. H., Behr, J., Ewert, R., Ghofrani, H. A., Gruenig, E., Halank, M., Held, M., Klose, H., Rosenkranz, S., Schermuly, R. T., Wilkens, H. and Hoeper, M. M. (2015). Riociguat: Stimulator of Soluble Guanylate-cyclase. Pneumologie, 69 (3). S. 135 - 144. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-8790

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Abstract

Riociguat is the first clinically available soluble Guanylate-cyclase stimulator (sGC) and representative of a completely new class of drugs. Riociguat is approved for pulmonary arterial hypertension (PAH) and non-operable or recurrent/persistent chronic thromboembolic pulmonary hypertension (CTEPH). Moreover, Riociguat is currently under investigation for a wider spectrum of diseases. This article focusses on its mode of action and clinical trial data. Finally, based on these data, the status of approval, as well as the costs a proposal is given how Riociguat can be integrated in the current treatment of PAH and CTEPH.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Leuchte, H. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behr, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewert, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghofrani, H. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruenig, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halank, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Held, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klose, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenkranz, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schermuly, R. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilkens, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoeper, M. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-411967
DOI: 10.1055/s-0034-1391435
Journal or Publication Title: Pneumologie
Volume: 69
Number: 3
Page Range: S. 135 - 144
Date: 2015
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1438-8790
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Respiratory SystemMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41196

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