Proels, Felicitas, Wiegreffe, Christoph and Scaal, Martin (2015). Communication between distant epithelial cells by filopodia-like protrusions during embryonic development. Development, 142 (4). S. 665 - 672. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 1477-9129

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Abstract

Long-range intercellular communication is essential for the regulation of embryonic development. Apart from simple diffusion, various modes of signal transfer have been described in the literature. Here, we describe a novel type of cellular extensions found in epithelial cells of the somites in chicken embryos. These filopodia-like protrusions span the subectodermal space overlying the dorsal surface of the somites and contact the ectoderm. We show that these protrusions are actin-and tubulin-positive and require Rac1 for their formation. The presence of glycophosphatidylinositol-anchored proteins and net retrograde trafficking of the transmembrane Wnt-receptor Frizzled-7 along the protrusions indicate their role in signal transport and distribution. Taken together, our data suggest a role of filopodia-like protrusions in mediating signaling events between distant epithelial cells during embryonic development.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Proels, FelicitasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiegreffe, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scaal, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-412417
DOI: 10.1242/dev.115964
Journal or Publication Title: Development
Volume: 142
Number: 4
Page Range: S. 665 - 672
Date: 2015
Publisher: COMPANY OF BIOLOGISTS LTD
Place of Publication: CAMBRIDGE
ISSN: 1477-9129
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GPI-ANCHORED PROTEINS; SURFACE ECTODERM; SOMITES; ORGANIZATION; CHICK; MECHANISM; HOMOLOG; RACMultiple languages
Developmental BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41241

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