Universität zu Köln

Stuermer, Konrad Johannes, Beutner, Dirk, Foerst, Astrid, Hahn, Moritz, Lang-Roth, Ruth and Walger, Martin (2015). Electrocochleography in children with auditory synaptopathy/neuropathy: Diagnostic findings and characteristic parameters. Int. J. Pediatr. Otorhinolaryngol., 79 (2). S. 139 - 146. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-8464

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Abstract

Introduction: The early diagnosis of AS/AN in children remains challenging because it exclusively relies on the detection of OAR and/or CM, while ABR are pathologically changed or missing. The aim of our study was to ensure the diagnosis of AS/AN, demarcate it to an outer hair cell damage and possibly differentiate between pre- and postsynaptic pathologies. Methods: We retrospectively evaluated the transtympanic ECochG results of ten children with AS/AN and compared them to a matched group with SNHL and without any signs of AS/AN. We analyzed the thresholds, latencies and - as a new parameter - the amplitude ratio between CAP and SP. Results: CM and SP thresholds were significantly lower than CAP thresholds in AS/AN patients and significantly lower than SP and CM thresholds in SNHL patients with comparable CAP thresholds. The CAP/SP ratio of amplitudes in SNHL children was more than three times (significantly) higher than in AS/AN children. The cutoff value was set at 1.0 in order to differentiate between both groups with a 80-90% sensitivity and specifity. It was not possible to differentiate between a pre- and postsynaptic type of AS/AN in our collective. Summary and conclusion: The ECochG can add valuable information for a precise differential diagnosis of AS/AN, especially in babyhood. We identified the CAP/SP ratio as a new parameter for differentiation between AS/AN and SNHL. When the CAP/SP ratio falls below 1.0, patients can be diagnosed AS/AN with high specificity and sensitivity. Significantly smaller SPL are needed to evoke SP and CM in the AS/AN group, thus showing the preserved hair cell function. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stuermer, Konrad Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Beutner, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerst, Astrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang-Roth, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Walger, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-413982
DOI:	10.1016/j.ijporl.2014.11.025
Journal or Publication Title:	Int. J. Pediatr. Otorhinolaryngol.
Volume:	79
Number:	2
Page Range:	S. 139 - 146
Date:	2015
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-8464
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEARING-LOSS; TRANSTYMPANIC ELECTROCOCHLEOGRAPHY; MENIERES-DISEASE; NEUROPATHY; POTENTIALS Multiple languages Otorhinolaryngology; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41398