Jayasinghe, Caren, Simiantonaki, Nektaria and Kirkpatrick, Charles James (2015). Histopathological features predict metastatic potential in locally advanced colon carcinomas. BMC Cancer, 15. LONDON: BIOMED CENTRAL LTD. ISSN 1471-2407

Full text not available from this repository.

Abstract

Background: Metastatic dissemination can exist before a pathologically and clinically detectable manifestation. The structural heterogeneity of colon cancer (CC) in histological sections with respect to the morphology of tumor aggressiveness and composition of the tumor microenvironment raises the question of whether the microscopical tumor architecture enables a discrimination of groups with different metastatic potential. This would result in an assessment of the prognosis and provision of an ancillary tool for the therapeutic management after surgery, beside the estimation of the local tumor extent. Methods: In order to identify predictive biomarkers for metastasis of locally advanced CC, which can easily be integrated into the pathologist's daily routine diagnostic activity, we determined tumor budding, peritumoral inflammation, extent of desmoplasia and necrosis, density of macro-and microvascular blood vessels and functional state of lymphatics in the tumor center, invasive margin and tumor-free surrounding tissue in 86 non-metastatic, lymphogenous-metastatic and haematogenous-metastatic, subserosa-invasive CC. Results: Features influencing nodal metastasis in the univariate analysis included high tumor budding (p = 0.004), high large vessel density in the subserosa (p = 0.043), abundant desmoplasia (p = 0.049), non-finger-like desmoplastic pattern (p = 0.051) and absent lymphocellular intratumoral inflammation (p = 0.084). In the multivariate analysis, with the exception of large vessel density, these pathomorphological features were independent risk factors for lymphogenous metastasis (p = 0.023, p = 0.017, p = 0.037, p = 0.012, respectively) with a good discrimination ability (AUC of 0.853). Features associated with distant metastasis in the univariate analysis included high tumor budding (p = 0.002), low intratumoral small vessel density (p = 0.013), absent lymphocellular intratumoral inflammation (p = 0.048) and abundant necrosis (p = 0.073). In the multivariate analysis only tumor budding was an independent predictor for haematogenous metastasis (p = 0.007) with a good discrimination ability (AUC of 0.829). Conclusions: Thus, mainly tumor budding but also the described structural characteristics of the peritumoral tissue appears to reflect the metastatic potential of locally advanced CC and therefore should be stated in pathological reports.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jayasinghe, CarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simiantonaki, NektariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirkpatrick, Charles JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-414462
DOI: 10.1186/s12885-015-1013-7
Journal or Publication Title: BMC Cancer
Volume: 15
Date: 2015
Publisher: BIOMED CENTRAL LTD
Place of Publication: LONDON
ISSN: 1471-2407
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COLORECTAL-CANCER PATIENTS; LYMPH-NODE METASTASIS; PROGNOSTIC MARKER; TUMOR NECROSIS; CELL INVASION; RISK-FACTOR; INFLAMMATION; DESMOPLASIA; EXPRESSION; DENSITYMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41446

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item