Glatz, Martin, Buchner, Matthias, Von Bartenwerffer, Wibke, Schmid-Grendelmeier, Peter, Worm, Margitta ORCID: 0000-0002-3449-1245, Hedderich, Juergen and Foelster-Holst, Regina (2015). Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults. Acta Derm.-Venereol., 95 (2). S. 191 - 197. UPPSALA: ACTA DERMATO-VENEREOLOGICA. ISSN 1651-2057

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Abstract

The significance of allergen-specific IgE as marker for severity of atopic dermatitis is controversial. The aim of this study was to determine the frequency of IgE-mediated sensitisation to food and environmental allergens in 132 children and 67 adults with atopic dermatitis, and its correlation to severity of atopic dermatitis (SCORAD). Total IgE was elevated (>100 KU/l) in 79.7% of adults and 46.8% of children. Sensitisation frequencies to allergens, particularly microbial allergens, were up to 10-fold higher in adults compared to children. Severity of atopic dermatitis correlated with elevated total IgE in adults (r=0.549, p<0.001) and children (r=0.344, p=0.005) and with Malassezia spp.-specific IgE in adults (r=0.429, p=0.007). Total IgE is a marker for severe atopic dermatitis in both age groups. Malassezia spp.-specific IgE is an important allergen-specific marker for severity of atopic dermatitis in adults.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Glatz, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchner, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Von Bartenwerffer, WibkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmid-Grendelmeier, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worm, MargittaUNSPECIFIEDorcid.org/0000-0002-3449-1245UNSPECIFIED
Hedderich, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foelster-Holst, ReginaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-417356
DOI: 10.2340/00015555-1864
Journal or Publication Title: Acta Derm.-Venereol.
Volume: 95
Number: 2
Page Range: S. 191 - 197
Date: 2015
Publisher: ACTA DERMATO-VENEREOLOGICA
Place of Publication: UPPSALA
ISSN: 1651-2057
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ALLERGEN-SPECIFIC IGE; DUST-MITE; MICROBIAL ALLERGENS; INTRINSIC FORM; FOOD ALLERGY; SCORAD INDEX; CHILDREN; SENSITIZATION; ECZEMA; FUNGALMultiple languages
DermatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41735

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