Universität zu Köln

Saez, Isabel and Vilchez, David ORCID: 0000-0002-0801-0743 (2015). Protein clearance mechanisms and their demise in age-related neurodegenerative diseases. AIMS Mol. Sci., 2 (1). S. 1 - 22. SPRINGFIELD: AMER INST MATHEMATICAL SCIENCES-AIMS. ISSN 2372-0301

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Abstract

The accumulation of damaged proteins contributes to the etiology of neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's or amyotrophic lateral sclerosis. Protein aggregation and deposition are common features of these disorders that share emergence patterns and are more frequent late in life, even though different toxic proteins are involved in their onset. The ability to maintain a functional proteome, or proteostasis, declines during the ageing process. Damaged proteins are degraded by the ubiquitin proteasome system or through autophagy- lysosome, key components of the proteostasis network. Here we review the links between neurodegenerative disorders and loss of protein clearance mechanisms with age.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Saez, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Vilchez, David UNSPECIFIED orcid.org/0000-0002-0801-0743 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-418300
DOI:	10.3934/molsci.2015.1.1
Journal or Publication Title:	AIMS Mol. Sci.
Volume:	2
Number:	1
Page Range:	S. 1 - 22
Date:	2015
Publisher:	AMER INST MATHEMATICAL SCIENCES-AIMS
Place of Publication:	SPRINGFIELD
ISSN:	2372-0301
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41830