Luening, Anna, Neugebauer, Michael, Lingen, Verena, Krest, Alexander, Stirnat, Kathrin, Deacon, Glen B., Drago, Penny R., Ott, Ingo ORCID: 0000-0002-8087-4618, Schur, Julia, Pantenburg, Ingo, Meyer, Gerd and Klein, Axel ORCID: 0000-0003-0093-9619 (2015). Platinum Diolefin Complexes - Synthesis, Structures, and Cytotoxicity. Eur. J. Inorg. Chem. (2). S. 226 - 240. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1099-0682

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Abstract

The synthesis, spectroscopy, structures and chemical reactivity of platinum(II) diolefin complexes cis-[(vertical bar(perpendicular to)vertical bar)PtCl2], cis-[(vertical bar(perpendicular to)vertical bar)PtCl(R)] and cis-[(vertical bar(perpendicular to)vertical bar)Pt(R)(2)] [vertical bar(perpendicular to)vertical bar = chelate diolefin ligand: 1,5-cyclooctadiene (COD), 1,5-dimethylocta-1,5-diene (Me2COD), norbornadiene (NBD), 1,5-hexadiene (HEX), 3-allyloxypropene (All(2)O, diallyl ether), diallylamine (All(2)NH); R = Me, Bn, C6F5, C6F4H-4 (or -5), or CC(4-Me)Ph] have been explored. The relative exchange rates of the cis-[(vertical bar(perpendicular to)vertical bar)PtCl2] complexes towards the diimine ligand diisopropyl-1,4-diazabutadiene (iPr-DAB) increased along the series COD< Me2COD< NBD< HEX< All(2)O by a factor of 4. The presumably dimeric complex [(All(2)NH)PtCl2](2) undergoes a unique rearrangement process in dimethyl sulfoxide (DMSO) solution to yield the dimeric piperazine complex [PtCl(dmso)(C6H10N)](2), which has been characterised by single-crystal XRD. For selected platinum complexes, cytotoxic effects in HT-29 colon carcinoma and MCF-7 breast cancer cell lines were evaluated. For comparison, the dicationic complexes [(COD)Pt(Bn)(L)][PF6](2) with the very labile coligands N-methyl-4,4-bipyridinium (MQ(+)) and N-methyl-1,4-pyrazinium (Mpz(+)) were added to the study. Although the hexadiene complexes [(HEX)Pt(C6F4H-4)(2)] and [(HEX)Pt(C6F4H-5)(2)] show strong cytotoxicity, the introduction of labile diolefin ligands or the labile cationic MQ(+) or Mpz(+) coligands does not generally lead to markedly increased cytotoxicity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Luening, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neugebauer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lingen, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krest, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stirnat, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deacon, Glen B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drago, Penny R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ott, IngoUNSPECIFIEDorcid.org/0000-0002-8087-4618UNSPECIFIED
Schur, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantenburg, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, AxelUNSPECIFIEDorcid.org/0000-0003-0093-9619UNSPECIFIED
URN: urn:nbn:de:hbz:38-418757
DOI: 10.1002/ejic.201402954
Journal or Publication Title: Eur. J. Inorg. Chem.
Number: 2
Page Range: S. 226 - 240
Date: 2015
Publisher: WILEY-V C H VERLAG GMBH
Place of Publication: WEINHEIM
ISSN: 1099-0682
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STABILIZED PHOSPHORUS YLIDES; SPECTROSCOPIC CHARACTERISTICS; NORBORNADIENE NBD; X-RAY; NUCLEOPHILIC-ATTACK; MOLECULAR-STRUCTURE; CRYSTAL-STRUCTURES; ANTICANCER DRUGS; ALKENE COMPLEXES; CELLULAR UPTAKEMultiple languages
Chemistry, Inorganic & NuclearMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/41875

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