Abken, Hinrich (2015). Adoptive therapy with CAR redirected T cells: the challenges in targeting solid tumors. Immunotherapy, 7 (5). S. 535 - 545. LONDON: FUTURE MEDICINE LTD. ISSN 1750-7448
Full text not available from this repository.Abstract
Recent spectacular success in the adoptive cell therapy of leukemia and lymphoma with chimeric antigen receptor (CAR)-modified T cells raised the expectations that this therapy may be efficacious in a wide range of cancer entities. The expectations are based on the predefined specificity of CAR T cells by an antibody-derived binding domain that acts independently of the natural T-cell receptor, recognizes targets independently of presentation by the major histocompatibility complex and allows targeting toward virtually any cell surface antigen. We here discuss that targeting CAR T cells toward solid tumors faces certain circumstances critical for the therapeutic success. Targeting tumor stroma and taking advantage of TRUCK cells, in other words, CAR T cells with inducible release of a transgenic payload, are some strategies envisaged to overcome current limitations in the near future.
Item Type: | Journal Article | ||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-419020 | ||||||||
DOI: | 10.2217/IMT.15.15 | ||||||||
Journal or Publication Title: | Immunotherapy | ||||||||
Volume: | 7 | ||||||||
Number: | 5 | ||||||||
Page Range: | S. 535 - 545 | ||||||||
Date: | 2015 | ||||||||
Publisher: | FUTURE MEDICINE LTD | ||||||||
Place of Publication: | LONDON | ||||||||
ISSN: | 1750-7448 | ||||||||
Language: | English | ||||||||
Faculty: | Unspecified | ||||||||
Divisions: | Unspecified | ||||||||
Subjects: | no entry | ||||||||
Uncontrolled Keywords: |
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URI: | http://kups.ub.uni-koeln.de/id/eprint/41902 |
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