Sitnikov, Nikolay S., Sinzov, Alexander V., Allegro, Diane, Barbier, Pascale, Combes, Sebastien, Onambele, Liliane Abodo, Prokop, Aram, Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 and Fedorov, Alexey Yu (2015). Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties. MedChemComm, 6 (12). S. 2158 - 2163. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 2040-2511

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Abstract

Based on the natural antimitotic agent allocolchicine as a lead structure, a series of novel indole-based allocolchicine congeners was synthesized and assessed in vitro for their cytostatic properties. Several compounds exhibited potent anti-proliferative and apoptosis-inducing activity towards lymphoma cells along with low unspecific cytotoxicity. The observed activity is supposed to result from the inhibition of microtubule assembly, as indicated by the tubulin polymerisation assay.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sitnikov, Nikolay S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sinzov, Alexander V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allegro, DianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbier, PascaleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Combes, SebastienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onambele, Liliane AbodoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prokop, AramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmalz, Hans-GuentherUNSPECIFIEDorcid.org/0000-0003-0489-1827UNSPECIFIED
Fedorov, Alexey YuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-419349
DOI: 10.1039/c5md00320b
Journal or Publication Title: MedChemComm
Volume: 6
Number: 12
Page Range: S. 2158 - 2163
Date: 2015
Publisher: ROYAL SOC CHEMISTRY
Place of Publication: CAMBRIDGE
ISSN: 2040-2511
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BIOLOGICAL EVALUATION; ASYMMETRIC-SYNTHESIS; B-RINGS; COLCHICINE; TUBULIN; AGENTS; DERIVATIVES; INHIBITION; ANALOGS; DESIGNMultiple languages
Biochemistry & Molecular Biology; Chemistry, MedicinalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/41934

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