Sabashnikov, Anton 
ORCID: 0000-0002-6289-1035, Weymann, Alexander, Mohite, Prashant N., Zych, Bartlomiej, Patil, Nikhil P., Saez, Diana Garcia, Popov, Aron-Frederik ORCID: 0000-0003-4226-3004, Zeriouh, Mohamed, Wahlers, Thorsten, Wittwer, Thorsten, Wippermann, Jens, De Robertis, Fabio, Bahrami, Toufan, Amrani, Mohamed and Simon, Andre R.
(2014).
Risk factors predictive of one-year mortality after lung transplantation.
Eur. J. Cardio-Thorac. Surg., 46 (6).
S. E82 - 7.
CARY:
OXFORD UNIV PRESS INC.
ISSN 1873-734X
Abstract
OBJECTIVES: Lung transplantation (LTx) is a life-saving therapy for patients with end-stage lung disease. However, there remains a significant postoperative complication rate and mortality in this extreme patient group. The aim of the present study was to identify donor, recipient and perioperative risk factors for one-year mortality after LTx. METHODS: A total of 252 LTxs were performed in our institution between 2007 and 2013. Donor and recipient demographics and clinical characteristics of 1-year survivors and non-survivors were collected and compared retrospectively. Multivariate logistic regression analysis was performed on univariate predictors for 1-year mortality with an entry criterion of P < 0.05. RESULTS: Multivariate analysis revealed female-to-male transplantation (95% CI: 0.088-0.767; P = 0.015), lower pO(2)/FiO(2)-ratio at 72 h postoperatively (95% CI: 0.988-0.999; P = 0.024), need for postoperative extracorporeal membrane oxygenation (ECMO) support (95% CI: 0.035-0.658; P = 0.012) and on-pump technique (95% CI: 0.007-0.944; P = 0.045) as the only independent predictors for 1-year mortality. Mainly unplanned intraoperative conversion to cardiopulmonary bypass contributed to poorer survival in patients who underwent LTx using cardiopulmonary bypass (P < 0.001). CONCLUSIONS: Our results show that the unplanned use of CPB (conversion from off-to on-pump) might adversely affect outcome after LTx. Also, the negative impact of female-to-male transplantation should not be underestimated during recipient selection. Furthermore, poor early postoperative oxygenation, particularly with the need for extracorporeal oxygenation, might be a very strong negative prognostic factor after LTx.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| URN: | urn:nbn:de:hbz:38-421209 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1093/ejcts/ezu383 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Eur. J. Cardio-Thorac. Surg. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Volume: | 46 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number: | 6 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Page Range: | S. E82 - 7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Date: | 2014 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | OXFORD UNIV PRESS INC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Place of Publication: | CARY | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1873-734X | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/42120 |
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