Universität zu Köln

Tellkamp, Frederik ORCID: 0000-0002-0473-7320, Vorhagen, Susanne and Niessen, Carien M. (2014). Epidermal Polarity Genes in Health and Disease. Cold Spring Harb. Perspect. Med., 4 (12). COLD SPRING HARBOR: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT. ISSN 2157-1422

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Abstract

The epidermis of the skin is a highly polarized, metabolic tissue with important innate immune functions. The polarity of the epidermis is, for example, reflected in controlled changes in cell shape that accompany differentiation, oriented cell division, and the planar orientation of hair follicles and cilia. The establishment and maintenance of polarity is organized by a diverse set of polarity proteins that include transmembrane adhesion proteins, cytoskeletal scaffold proteins, and kinases. Although polarity proteins have been extensively studied in cell culture and in vivo in simple epithelia of lower organisms, their role in mammalian tissue biology is only slowly evolving. This article will address the importance of polarizing processes and their molecular regulators in epidermal morphogenesis and homeostasis and discuss how alterations in polarity may contribute to skin disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tellkamp, Frederik UNSPECIFIED orcid.org/0000-0002-0473-7320 UNSPECIFIED Vorhagen, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Niessen, Carien M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-421451
DOI:	10.1101/cshperspect.a015255
Journal or Publication Title:	Cold Spring Harb. Perspect. Med.
Volume:	4
Number:	12
Date:	2014
Publisher:	COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Place of Publication:	COLD SPRING HARBOR
ISSN:	2157-1422
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASYMMETRIC CELL DIVISIONS; HAIR FOLLICLE MORPHOGENESIS; MITOTIC SPINDLE ORIENTATION; EPITHELIAL STEM-CELLS; KINASE C-IOTA; PROTEIN-KINASE; TUMOR-SUPPRESSOR; PRIMARY CILIUM; PKC-LAMBDA; MICROTUBULE ORGANIZATION Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42145