Universität zu Köln

Thevis, Mario and Schaenzer, Wilhelm (2014). Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls. J. Pharm. Biomed. Anal., 101. S. 66 - 84. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-264X

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Abstract

The number and diversity of potentially performance-enhancing substances is continuously growing, fueled by new pharmaceutical developments but also by the inventiveness and, at the same time, unscrupulousness of black-market (designer) drug producers and providers. In terms of sports drug testing, this situation necessitates reactive as well as proactive research and expansion of the analytical armamentarium to ensure timely, adequate, and comprehensive doping controls. This review summarizes literature published over the past 5 years on new drug entities, discontinued therapeutics, and 'tailored' compounds classified as doping agents according to the regulations of the World Anti-Doping Agency, with particular attention to analytical strategies enabling their detection in human blood or urine. Among these compounds, low- and high-molecular mass substances of peptidic (e.g. modified insulin-like growth factor-1, TB-500, hematide/peginesatide, growth hormone releasing peptides, AOD-9604, etc.) and non-peptidic (selective androgen receptor modulators, hypoxia-inducible factor stabilizers, siRNA, S-107 and ARM036/aladorian, etc.) as well as inorganic (cobalt) nature are considered and discussed in terms of specific requirements originating from physicochemical properties, concentration levels, metabolism, and their amenability for chromatographic-mass spectrometric or alternative detection methods. (C) 2014 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaenzer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-421988
DOI:	10.1016/j.jpba.2014.05.020
Journal or Publication Title:	J. Pharm. Biomed. Anal.
Volume:	101
Page Range:	S. 66 - 84
Date:	2014
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1873-264X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANDROGEN RECEPTOR MODULATOR; OBSTRUCTIVE PULMONARY-DISEASE; MASS-SPECTROMETRIC DETECTION; DRIED BLOOD SPOTS; MECHANO-GROWTH-FACTOR; RECOMBINANT HUMAN ERYTHROPOIETINS; VITRO GENERATED METABOLITES; HORMONE-RELEASING PEPTIDE; SIRT1 ACTIVATING DRUGS; BLACK-MARKET PRODUCTS Multiple languages Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42198