Universität zu Köln

Reinhardt, A., Horn, M., Schmauck, J. Pieper Gen, Broehl, A., Giernoth, R., Oelkrug, C., Schubert, A. and Neundorf, I. (2014). Novel Imidazolium Salt-Peptide Conjugates and Their Antimicrobial Activity. Bioconjugate Chem., 25 (12). S. 2166 - 2175. WASHINGTON: AMER CHEMICAL SOC. ISSN 1043-1802

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Abstract

Our study presents innovative research dealing with the synthesis and biological evaluation of conjugates out of antimicrobial peptides (AMPs) and imidazolium cations that are derived from ionic liquids. AMPs are considered as promising alternatives to common antibiotics due to their different activity mechanisms. Antibacterial effects have also been described for ionic liquids bearing imidazolium cations . Besides single coupling of carboxy-functionalized imidazolium cations to the peptide N-terminal we also developed conjugates bearing multiple copies of imidazolium cations. The combination of both compounds resulted in synergistic effects that were most pronounced when more imidazolium cations were attached to the peptides. In addition, antibacterial activity even in drug-resistant bacterial strains could be observed. Moreover, the novel compounds showed good selectivity only against bacterial cells, an observation that was further proven by lipid interaction studies using giant unilamellar vesicles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reinhardt, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmauck, J. Pieper Gen UNSPECIFIED UNSPECIFIED UNSPECIFIED Broehl, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Giernoth, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oelkrug, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schubert, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neundorf, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422387
DOI:	10.1021/bc500510c
Journal or Publication Title:	Bioconjugate Chem.
Volume:	25
Number:	12
Page Range:	S. 2166 - 2175
Date:	2014
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	1043-1802
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IONIC LIQUIDS; PHOSPHOLIPID-MEMBRANES; INNATE IMMUNITY; CANCER-CELLS; MECHANISM; BACTERIA; PROTEIN; MODEL Multiple languages Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Multidisciplinary; Chemistry, Organic Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42238