Universität zu Köln

Scheuing, Nicole, Holl, Reinhard W., Dockter, Gerd, Hermann, Julia M., Junge, Sibylle, Koerner-Rettberg, Cordula, Naehrlich, Lutz ORCID: 0000-0002-7146-6997, Smaczny, Christina, Staab, Doris, Thalhammer, Gabriela, van Koningsbruggen-Rietschel, Silke and Ballmann, Manfred (2014). High Variability in Oral Glucose Tolerance among 1,128 Patients with Cystic Fibrosis: A Multicenter Screening Study. PLoS One, 9 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background: In cystic fibrosis, highly variable glucose tolerance is suspected. However, no study provided within-patient coefficients of variation. The main objective of this short report was to evaluate within-patient variability of oral glucose tolerance. Methods: In total, 4,643 standardized oral glucose tolerance tests of 1,128 cystic fibrosis patients (median age at first test: 15.5 [11.5; 21.5] years, 48.8% females) were studied. Patients included were clinically stable, non-pregnant, and had at least two oral glucose tolerance tests, with no prior lung transplantation or systemic steroid therapy. Transition frequency from any one test to the subsequent test was analyzed and within-patient coefficients of variation were calculated for fasting and two hour blood glucose values. All statistical analysis was implemented with SAS 9.4. Results: A diabetic glucose tolerance was confirmed in 41.2% by the subsequent test. A regression to normal glucose tolerance at the subsequent test was observed in 21.7% and to impaired fasting glucose, impaired glucose tolerance or both in 15.2%, 12.0% or 9.9%. The average within-patient coefficient of variation for fasting blood glucose was 11.1% and for two hour blood glucose 25.3%. Conclusion: In the cystic fibrosis patients studied, a highly variable glucose tolerance was observed. Compared to the general population, variability of two hour blood glucose was 1.5 to 1.8-fold higher.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scheuing, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, Reinhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dockter, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermann, Julia M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Junge, Sibylle UNSPECIFIED UNSPECIFIED UNSPECIFIED Koerner-Rettberg, Cordula UNSPECIFIED UNSPECIFIED UNSPECIFIED Naehrlich, Lutz UNSPECIFIED orcid.org/0000-0002-7146-6997 UNSPECIFIED Smaczny, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Staab, Doris UNSPECIFIED UNSPECIFIED UNSPECIFIED Thalhammer, Gabriela UNSPECIFIED UNSPECIFIED UNSPECIFIED van Koningsbruggen-Rietschel, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Ballmann, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-423357
DOI:	10.1371/journal.pone.0112578
Journal or Publication Title:	PLoS One
Volume:	9
Number:	11
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREVALENCE; CHILDREN Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42335