Finger, Fabian ORCID: 0000-0002-0763-6250 and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2014). MicroRNAs meet calcium: Joint venture in ER proteostasis. Sci. Signal., 7 (350). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1937-9145

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Abstract

The endoplasmic reticulum (ER) is a cellular compartment that has a key function in protein translation and folding. Maintaining its integrity is of fundamental importance for organism's physiology and viability. The dynamic regulation of intraluminal ER Ca2+ concentration directly influences the activity of ER-resident chaperones and stress response pathways that balance protein load and folding capacity. We review the emerging evidence that microRNAs play important roles in adjusting these processes to frequently changing intracellular and environmental conditions to modify ER Ca2+ handling and storage and maintain ER homeostasis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Finger, FabianUNSPECIFIEDorcid.org/0000-0002-0763-6250UNSPECIFIED
Hoppe, ThorstenUNSPECIFIEDorcid.org/0000-0002-4734-9352UNSPECIFIED
URN: urn:nbn:de:hbz:38-423589
DOI: 10.1126/scisignal.2005671
Journal or Publication Title: Sci. Signal.
Volume: 7
Number: 350
Date: 2014
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication: WASHINGTON
ISSN: 1937-9145
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ENDOPLASMIC-RETICULUM STRESS; PROTEIN DISULFIDE-ISOMERASE; CAENORHABDITIS-ELEGANS; SARCOPLASMIC-RETICULUM; ISCHEMIA/REPERFUSION INJURY; INFLUENZA HEMAGGLUTININ; INOSITOL TRISPHOSPHATE; BINDING-PROTEIN; CARDIAC-MUSCLE; CA2+Multiple languages
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/42358

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