Universität zu Köln

Zirkel, Anne and Papantonis, Argyris ORCID: 0000-0001-7551-1073 (2014). Transcription as a force partitioning the eukaryotic genome. Biol. Chem., 395 (11). S. 1301 - 1306. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1437-4315

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Abstract

Eukaryotic genomes - until recently dealt with as if they were a cohort of linear DNA molecules - are perplexed three-dimensional structures, the exact conformation of which profoundly affects genome function. Recent advances in molecular biology and DNA sequencing technologies have led to a new understanding of the folding of chromatin in the nucleus. Changes in chromatin structure underlie deployment of new gene expression programs during development, differentiation, or disease. In this review, we revisit data pointing to, arguably, the major force that shapes genomes: transcription of DNA into RNA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zirkel, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Papantonis, Argyris UNSPECIFIED orcid.org/0000-0001-7551-1073 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-424937
DOI:	10.1515/hsz-2014-0196
Journal or Publication Title:	Biol. Chem.
Volume:	395
Number:	11
Page Range:	S. 1301 - 1306
Date:	2014
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	1437-4315
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHROMATIN INTERACTIONS; CONFORMATION CAPTURE; COREGULATED GENES; HUMAN-CELLS; FACTORIES; ORGANIZATION; PLURIPOTENCY; CHROMOSOME; REVEALS; DIFFERENTIATION Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42493