Petrelli, Annette, Kaesberg, Stephanie, Barbe, Michael T., Timmermann, Lars, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Kessler, Josef and Kalbe, Elke (2014). Effects of cognitive training in Parkinson's disease: A randomized controlled trial. Parkinsonism Relat. Disord., 20 (11). S. 1196 - 1203. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Background: In Parkinson's Disease (PD), cognitive dysfunctions which can reduce patients' quality of life occur frequently. Data on non-pharmacological intervention effects on cognitive functions in patients with PD are rare. The aim of this study was to examine the effects of different cognitive group trainings (structured vs. unstructured) on cognition, depression, and quality of life in non-demented PD patients. Methods: In this randomized controlled trial, 65 non-demented patients with PD according to UK Brain Bank criteria (Hoehn & Yahr I-III) were allocated to one of two cognitive multi-component treatments (NEUROvitalis, a structured training, or the unstructured training Mentally fit with randomly assembled cognitive tasks, each including 12 group-sessions a 90 min over 6 weeks) or a waiting list control group (CG). A neuropsychological test battery was performed before and after the training. Results: Compared to the CG, patients from the NEUROvitalis group improved in short-term memory (word list learning Memo: p < .01) and working memory (digit span reverse from DemTect: p < .05), whereas depression scores where reduced in the Mentally fit group (Beck Depression Inventory-II: p < .05). The NEUROvitalis group improved significantly more in working memory than the Mentally fit group (DemTect: p < .05). Discussion: Cognitive and affective functions can be improved by cognitive trainings in PD patients. Specific effects (e.g. on memory and working memory versus depression) seem to be dependent on the type of training. Further research is needed to define long-term effects and the efficacy in PD patients with different extent of cognitive and neuropsychiatric symptoms. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Petrelli, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaesberg, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Kessler, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-425321
DOI: 10.1016/j.parkreldis.2014.08.023
Journal or Publication Title: Parkinsonism Relat. Disord.
Volume: 20
Number: 11
Page Range: S. 1196 - 1203
Date: 2014
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1873-5126
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EXECUTIVE FUNCTIONS; OLDER-ADULTS; IMPAIRMENT; EFFICACY; WORKING; MEMORYMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/42532

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