Universität zu Köln

Thiel, Daniel, Doknic, Diana and Deska, Jan ORCID: 0000-0003-4622-2365 (2014). Enzymatic aerobic ring rearrangement of optically active furylcarbinols. Nat. Commun., 5. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Full text not available from this repository.

Abstract

Biogenic furans are currently discussed as highly attractive alternative feedstock in a post-fossil society; thus, also the creation of sustainable furan valorization pathways appears of great importance. Here an artificial Achmatowicz monooxygenase activity for the aerobic ring expansion of furans is achieved by the combination of commercial glucose oxidase as oxygen-activating biocatalyst and wild-type chloroperoxidase as oxygen-transfer mediator, providing a biological ready-to-use solution for this truly synthetic furan rearrangement. In concert with enzymatic transformations for the enantioselective preparation of optically active furylcarbinols, purely biocatalytic reaction cascades for the stereocontrolled construction of complex pyranones are obtained, exhibiting high functional group tolerance even to oxidation-sensitive moieties.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thiel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Doknic, Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED Deska, Jan UNSPECIFIED orcid.org/0000-0003-4622-2365 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-426563
DOI:	10.1038/ncomms6278
Journal or Publication Title:	Nat. Commun.
Volume:	5
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEXT-GENERATION; CHLOROPEROXIDASE; BIOMASS; TRANSFORMATION; EPOXIDATION; CHEMICALS; ENZYMES Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42656