Universität zu Köln

Doerler, Martin, Eming, Sabine, Dissemond, Joachim, Wolter, Anneke, Stoffels-Weindorf, Maren, Reich-Schupke, Stefanie, Altmeyer, Peter and Stuecker, Markus (2014). A Novel Epidermal Growth Factor-Containing Wound Dressing for the Treatment of Hard-to-Heal Venous Leg Ulcers. Adv. Skin Wound Care, 27 (10). S. 456 - 461. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1538-8654

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Abstract

OBJECTIVE: To evaluate the efficacy, tolerability, and safety of a novel wound dressing containing epidermal growth factor (EGF) in a collagen-gel matrix on hard-to-heal venous leg ulcers. PATIENTS AND METHODS: The authors included 33 hard-to-heal venous leg ulcers found on 31 patients. The EGF-containing dressing was applied 3 times while best practice conservative wound treatment was continued. Patients were followed up with after 1, 2, and 3 months to evaluate (a) the wound size, (b) the ease of application and dissolution of the dressing, and (c) the wound dressing by means of a scale ranging from 1 to 5 (1 = best, 5 = worst). RESULTS: The protocol was completed by 25 of 31 patients. The reasons for discontinuation were wound infection, pain, and lost to follow-up (n = 2 each, respectively). After 3 months, the average wound surface was significantly reduced (from 33.69 cm(2) to 18.94 cm(2), P = .023). On a scale from 0 to 100, the wound dressing was evaluated as very easy to apply and highly dissolvable (mean value of 97.14 and 98.11, respectively; 100 = very easy to apply or 100% dissolution). The dressing was generally well tolerated and scored a mean overall rating of 2.16 by healthcare specialists and 2.40 by patients. CONCLUSION: The authors' results demonstrate that the novel EGF-containing wound dressing was generally well tolerated and safe. Combined with the significant wound surface reduction, it can be regarded as an adequate novel treatment option for patients with hard-to-heal venous leg ulcers.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Doerler, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Eming, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Dissemond, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolter, Anneke UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels-Weindorf, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Reich-Schupke, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Altmeyer, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuecker, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-427463
DOI:	10.1097/01.ASW.0000451942.39446.c2
Journal or Publication Title:	Adv. Skin Wound Care
Volume:	27
Number:	10
Page Range:	S. 456 - 461
Date:	2014
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1538-8654
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULCERATION ESCHAR; COMPRESSION; SURGERY; TRIAL Multiple languages Dermatology; Nursing; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42746