Andree, Maria, Seeger, Jens M., Schuell, Stephan, Coutelle, Oliver, Wagner-Stippich, Diana, Wiegmann, Katja, Wunderlich, Claudia M., Brinkmann, Kerstin, Broxtermann, Pia, Witt, Axel, Fritsch, Melanie, Martinelli, Paola, Bielig, Harald, Lamkemeyer, Tobias, Rugarli, Elena I., Kaufmann, Thomas ORCID: 0000-0001-9906-874X, Sterner-Kock, Anja, Wunderlich, F. Thomas, Villunger, Andreas, Martins, L. Miguel, Kroenke, Martin, Kufer, Thomas A., Utermoehlen, Olaf and Kashkar, Hamid (2014). BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. Embo J., 33 (19). S. 2171 - 2188. HOBOKEN: WILEY. ISSN 1460-2075

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Abstract

The X-linked inhibitor of apoptosis protein (XIAP) is a potent caspase inhibitor, best known for its anti-apoptotic function in cancer. During apoptosis, XIAP is antagonized by SMAC, which is released from the mitochondria upon caspase-mediated activation of BID. Recent studies suggest that XIAP is involved in immune signaling. Here, we explore XIAP as an important mediator of an immune response against the enteroinvasive bacterium Shigella flexneri, both in vitro and in vivo. Our data demonstrate for the first time that Shigella evades the XIAP-mediated immune response by inducing the BID-dependent release of SMAC from the mitochondria. Unlike apoptotic stimuli, Shigella activates the calpain-dependent cleavage of BID to trigger the release of SMAC, which antagonizes the inflammatory action of XIAP without inducing apoptosis. Our results demonstrate how the cellular death machinery can be subverted by an invasive pathogen to ensure bacterial colonization.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Andree, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seeger, Jens M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuell, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coutelle, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner-Stippich, DianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiegmann, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wunderlich, Claudia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brinkmann, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broxtermann, PiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fritsch, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinelli, PaolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bielig, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamkemeyer, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rugarli, Elena I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaufmann, ThomasUNSPECIFIEDorcid.org/0000-0001-9906-874XUNSPECIFIED
Sterner-Kock, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wunderlich, F. ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villunger, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martins, L. MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroenke, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kufer, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Utermoehlen, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kashkar, HamidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-427945
DOI: 10.15252/embj.201387244
Journal or Publication Title: Embo J.
Volume: 33
Number: 19
Page Range: S. 2171 - 2188
Date: 2014
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1460-2075
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NF-KAPPA-B; CELL-DEATH; ACTIVATION; EXPRESSION; APOPTOSIS; PROTEIN; INFLAMMATION; DEFICIENCY; INFECTION; INHIBITIONMultiple languages
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/42794

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