Universität zu Köln

Kumari, Snehlata, Herzberg, Benjamin, Pofahl, Ruth, Krieg, Thomas and Haase, Ingo (2014). Epidermal RelA Specifically Restricts Contact Allergen-Induced Inflammation and Apoptosis in Skin. J. Invest. Dermatol., 134 (10). S. 2541 - 2551. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1523-1747

Full text not available from this repository.

Abstract

Strong inhibition of NF-kappa B signaling in the epidermis results in spontaneous skin inflammation in mice and men. As there is evidence for linkage between polymorphisms within the NF-kappa B signaling pathway and human inflammatory skin phenotypes, we asked whether partial functional inhibition of NF-kappa B signaling in epidermal keratinocytes can modulate clinically relevant skin inflammation. We therefore mutated rela specifically in the epidermis of mice (RelA(E-MUT) mice). These mice show no inflammatory phenotype. Induction of contact allergy, but not croton oil-induced irritant dermatitis, resulted in stronger ear swelling and increased epidermal thickness in RelA(E-MUT) mice. Both contact allergen and croton oil treatment led to increased expression of calgranulins A and B (S100A8/A9) in RelA(E-MUT) mice. Epidermal hyperproliferation in RelA(E-MUT) mice was non-cell autonomous as cultured primary epidermal keratinocytes from RelA(E-MUT) mice showed reduced proliferation compared with controls. These results demonstrate that epidermal RelA specifically regulates delayed-type hypersensitivity-induced skin inflammation. In addition, we describe here an essential but nonspecific function of RelA in the protection of epidermal keratinocytes from apoptosis. Our study identifies functions of NF-kappa B signaling in the epidermis and corroborates a specific role of epidermal keratinocytes in the regulation of skin inflammation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kumari, Snehlata UNSPECIFIED UNSPECIFIED UNSPECIFIED Herzberg, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Pofahl, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Krieg, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Haase, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-428149
DOI:	10.1038/jid.2014.193
Journal or Publication Title:	J. Invest. Dermatol.
Volume:	134
Number:	10
Page Range:	S. 2541 - 2551
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1523-1747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; ANHIDROTIC ECTODERMAL DYSPLASIA; INDUCED KERATINOCYTE APOPTOSIS; INCONTINENTIA PIGMENTI; TRANSCRIPTION FACTORS; ENDOTHELIAL-CELLS; IMMUNE-RESPONSES; XAF1 EXPRESSION; DEFICIENT MICE; ALPHA MUTATION Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42814