Universität zu Köln

Ritter, Christian, Foerster, Dominik, Albrecht, Philipp, Hartung, Hans-Peter, Kieseier, Bernd C. and Lehmann, Helmar C. (2014). IVIG regulates BAFF expression in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). J. Neuroimmunol., 274 (1-2). S. 225 - 230. AMSTERDAM: ELSEVIER. ISSN 1872-8421

Full text not available from this repository.

Abstract

Recent studies indicate that the cytokine B-cell activating factor (BAFF) is involved in the pathogenesis of chronic inflammatory demyelinating polyneuropathy (CIDP). Intravenous immunoglobulin (IVIg) is standard treatment for CIDP and is known to rapidly modulate increased serum levels of pro-inflammatory cytokines. We evaluated the expression profile of BAFF and its corresponding BAFF-receptor in samples from CIDP patients, focusing on rapid changes before and after IVIg treatment In CIDP patients BAFF serum concentrations were elevated compared to controls. Treatment with high-dose IVIg restored those elevated BAFF serum levels. Whereas treatment with IVIg did not affect BAFF production in monocytes, antibodies against BAFF could be detected in IVIg preparations, which may explain the short-term decrease of BAFF levels after IVIg treatment. Our data suggest that BAFF plays an important role in the pathogenesis of CIDP and may serve as marker for IVIg treatment response. (C) 2014 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ritter, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerster, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Albrecht, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartung, Hans-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Kieseier, Bernd C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-428657
DOI:	10.1016/j.jneuroim.2014.06.007
Journal or Publication Title:	J. Neuroimmunol.
Volume:	274
Number:	1-2
Page Range:	S. 225 - 230
Date:	2014
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1872-8421
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B-LYMPHOCYTE STIMULATOR; ACTIVATING FACTOR BAFF; BLOOD-PLASMA CONCENTRATIONS; NECROSIS-FACTOR FAMILY; INTRAVENOUS IMMUNOGLOBULIN; T-CELL; THERAPEUTIC TARGETS; BAFF/APRIL SYSTEM; POLYRADICULONEUROPATHY; OVEREXPRESSION Multiple languages Immunology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42865