Universität zu Köln

Missios, Pavlos, Zhou, Yuan, Guachalla, Luis Miguel ORCID: 0000-0003-1152-9930, von Figura, Guido, Wegner, Andre, Chakkarappan, Sundaram Reddy, Binz, Tina ORCID: 0000-0001-6783-1202, Gompf, Anne, Hartleben, Goetz, Burkhalter, Martin D., Wulff, Veronika, Guenes, Cagatay, Sattler, Rui Wang, Song, Zhangfa ORCID: 0000-0001-6301-1813, Illig, Thomas, Klaus, Susanne ORCID: 0000-0001-8726-185X, Boehm, Bernhard O., Wenz, Tina, Hiller, Karsten and Rudolph, K. Lenhard (2014). Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice. Nat. Commun., 5. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Full text not available from this repository.

Abstract

DNA damage and telomere dysfunction shorten organismal lifespan. Here we show that oral glucose administration at advanced age increases health and lifespan of telomere dysfunctional mice. The study reveals that energy consumption increases in telomere dysfunctional cells resulting in enhanced glucose metabolism both in glycolysis and in the tricarboxylic acid cycle at organismal level. In ageing telomere dysfunctional mice, normal diet provides insufficient amounts of glucose thus leading to impaired energy homeostasis, catabolism, suppression of IGF-1/mTOR signalling, suppression of mitochondrial biogenesis and tissue atrophy. A glucose-enriched diet reverts these defects by activating glycolysis, mitochondrial biogenesis and oxidative glucose metabolism. The beneficial effects of glucose substitution on mitochondrial function and glucose metabolism are blocked by mTOR inhibition but mimicked by IGF-1 application. Together, these results provide the first experimental evidence that telomere dysfunction enhances the requirement of glucose substitution for the maintenance of energy homeostasis and IGF-1/mTOR-dependent mitochondrial biogenesis in ageing tissues.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Missios, Pavlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhou, Yuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Guachalla, Luis Miguel UNSPECIFIED orcid.org/0000-0003-1152-9930 UNSPECIFIED von Figura, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegner, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Chakkarappan, Sundaram Reddy UNSPECIFIED UNSPECIFIED UNSPECIFIED Binz, Tina UNSPECIFIED orcid.org/0000-0001-6783-1202 UNSPECIFIED Gompf, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartleben, Goetz UNSPECIFIED UNSPECIFIED UNSPECIFIED Burkhalter, Martin D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wulff, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Guenes, Cagatay UNSPECIFIED UNSPECIFIED UNSPECIFIED Sattler, Rui Wang UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Zhangfa UNSPECIFIED orcid.org/0000-0001-6301-1813 UNSPECIFIED Illig, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Klaus, Susanne UNSPECIFIED orcid.org/0000-0001-8726-185X UNSPECIFIED Boehm, Bernhard O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenz, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hiller, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, K. Lenhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-431349
DOI:	10.1038/ncomms5924
Journal or Publication Title:	Nat. Commun.
Volume:	5
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-HORMONE; MITOCHONDRIAL; RESTRICTION; CELLS; LONGEVITY; MORTALITY; SURVIVAL; KINASE Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43134