Universität zu Köln

Vitinius, Frank, Hellmich, Martin, Matthies, Annalena, Bornkessel, Fabian, Burghart, Heiner, Albus, Christian, Huettenbrink, Karl-Bernd and Vent, Julia (2014). Feasibility of an interval, inspiration-triggered nocturnal odorant application by a novel device: a patient-blinded, randomised crossover, pilot trial on mood and sleep quality of depressed female inpatients. Eur. Arch. Oto-Rhino-Laryn., 271 (9). S. 2443 - 2455. NEW YORK: SPRINGER. ISSN 1434-4726

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Abstract

It has been suggested that certain odorants positively affect mood, but this has not yet been scientifically tested in humans. The aim of the current study was to demonstrate the feasibility of a new odorant applicator and to assess the effects of nocturnal intermittent rose odorant application on mood, and quality of sleep and dreams in depressed female inpatients. We hypothesised that mood as primary outcome will improve. Twenty-seven normosmic, 18- to 49-year-old female, depressed inpatients were investigated in a randomised, placebo-controlled, crossover study. Exclusion criteria were rhinitis, hyp- or anosmia. During sleep, an interval-controlled, inspiration-triggered applicator added rose concentrate to the inspirated air. There were three consecutive nights of each odorant and placebo application and a wash-out phase. Patients completed standardised questionnaires on mood, dreams, and sleep quality. Four patients dropped out (n = 1: non-compliance in filling in the questionnaires, n = 3: intolerance of nasal tube). Otherwise, this novel odorant applicator was well tolerated. Application of the odorant showed no significant mood differences between rose and placebo, however, some subdomains of sleep quality and mood showed a positive trend towards improvement by rose application. The feasibility of this new device and of nasal tubes could be shown. Odorant application is well tolerated. It may have a positive influence on quality of mood and sleep in depressed patients. A longer application phase is planned to obtain convincing evidence for our hypothesis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vitinius, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthies, Annalena UNSPECIFIED UNSPECIFIED UNSPECIFIED Bornkessel, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Burghart, Heiner UNSPECIFIED UNSPECIFIED UNSPECIFIED Albus, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Huettenbrink, Karl-Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Vent, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-431756
DOI:	10.1007/s00405-013-2873-6
Journal or Publication Title:	Eur. Arch. Oto-Rhino-Laryn.
Volume:	271
Number:	9
Page Range:	S. 2443 - 2455
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1434-4726
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL-TRIAL; OLFACTORY LOSS; NORMATIVE DATA; ROSE OIL; IDENTIFICATION; INFORMATION; INHALATION; FRAGRANCE; EMOTIONS; MICE Multiple languages Otorhinolaryngology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43175