Universität zu Köln

Banerjee, Sanjita and Leptin, Maria ORCID: 0000-0001-7097-348X (2014). Systemic Response to Ultraviolet Radiation Involves Induction of Leukocytic IL-1 beta and Inflammation in Zebrafish. J. Immunol., 193 (3). S. 1408 - 1416. BETHESDA: AMER ASSOC IMMUNOLOGISTS. ISSN 1550-6606

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Abstract

Ultraviolet radiation is a pervasive stimulus with wide-ranging effects on all living forms. The effects of UV vary from physiological to pathological, depending on levels of exposure, but the immune response at the organismal level is not well understood. We use the zebrafish embryo and larva to study immune responses to UV stress in vivo. UV exposure causes inflammation characterized by systemic induction of proinflammatory cytokines. Leukocytes are an important component of this systemic response and upregulate IL-1 beta expression proportional to the dose of UV exposure. Increased levels of this proinflammatory cytokine counteract the lethal effect of high doses of UV.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Banerjee, Sanjita UNSPECIFIED UNSPECIFIED UNSPECIFIED Leptin, Maria UNSPECIFIED orcid.org/0000-0001-7097-348X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433037
DOI:	10.4049/jimmunol.1400232
Journal or Publication Title:	J. Immunol.
Volume:	193
Number:	3
Page Range:	S. 1408 - 1416
Date:	2014
Publisher:	AMER ASSOC IMMUNOLOGISTS
Place of Publication:	BETHESDA
ISSN:	1550-6606
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; REGULATORY T-CELLS; IN-VIVO; HUMAN KERATINOCYTES; GENE-EXPRESSION; ACTIVATION; MICE; INTERLEUKIN-1-BETA; IL-10; SUPPRESSION Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/43303