Universität zu Köln

Pfister, Roman, Michels, Guido, Sharp, Stephen J., Luben, Robert, Wareham, Nick J. and Khaw, Kay-Tee (2014). Low Bone Mineral Density Predicts Incident Heart Failure in Men and Women The EPIC (European Prospective Investigation Into Cancer and Nutrition)-Norfolk Prospective Study. JACC-Heart Fail., 2 (4). S. 380 - 390. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1787

Full text not available from this repository.

Abstract

OBJECTIVES It is unknown whether bone mineral density as a measure of osteoporosis is associated with development of heart failure. BACKGROUND Recent evidence suggests shared risk factors between heart failure and osteoporosis. Additionally, patients with osteoporosis are at increased risk for cardiovascular disease. METHODS We examined the prospective association of bone mineral density measured as broadband ultrasound attenuation by quantitative ultrasound of the heel with incident heart failure events in 13,666 apparently healthy persons 42 to 82 years of age participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study in Norfolk, United Kingdom. RESULTS During a mean follow-up of 9.3 years, 380 incident cases of heart failure occurred. The risk of heart failure decreased with increasing bone mineral density. The hazard ratios comparing each quartile with the lowest were 0.40 (95% confidence intervals [CI]: 0.27 to 0.59), 0.54 (95% CI: 0.37 to 0.79), and 0.46 (95% CI: 0.32 to 0.68) in analysis adjusting for age, sex, smoking, alcohol consumption, physical activity, occupational social class, educational level, systolic blood pressure, diabetes, cholesterol concentration, and body mass index (p for trend = 0.002), with a 23% risk decrease associated with every increase in 1 standard deviation of bone mineral density (hazard ratio [HR]: 0.77; 95% CI: 0.66 to 0.89). The association was stronger with heart failure without (HR: 0.75; 95% CI: 0.63 to 0.89) than with antecedent myocardial infarction (HR: 0.82; 95% CI: 0.62 to 1.09). CONCLUSIONS We observed an inverse association between bone mineral density and the risk of heart failure in apparently healthy individuals. Our findings give support for cardiac assessment in people with reduced bone mineral density and warrant further exploration of underlying biological mechanisms linking osteoporosis and heart failure. (C) 2014 by the American College of Cardiology Foundation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pfister, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharp, Stephen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Luben, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Wareham, Nick J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Khaw, Kay-Tee UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433328
DOI:	10.1016/j.jchf.2014.03.010
Journal or Publication Title:	JACC-Heart Fail.
Volume:	2
Number:	4
Page Range:	S. 380 - 390
Date:	2014
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1787
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; QUANTITATIVE ULTRASOUND; POSTMENOPAUSAL WOMEN; FRACTURE RISK; HIP FRACTURE; TASK-FORCE; OSTEOPOROSIS; ASSOCIATION; DIAGNOSIS Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43332