Universität zu Köln

Ermolaeva, Maria A. and Schumacher, Bjoern (2014). Insights from the worm: The C. elegans model for innate immunity. Semin. Immunol., 26 (4). S. 303 - 310. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1096-3618

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Abstract

The nematode worm Caenorhabditis elegans comprises an ancestral immune system. C elegans recognizes and responds to viral, bacterial, and fungal infections. Components of the RNA interference machinery respond to viral infection, while highly conserved MAPK signaling pathways activate the innate immune response to bacterial infection. C. elegans has been particularly important for exploring the role of innate immunity in organismal stress resistance and the regulation of longevity. Also functions of neuronal sensing of infectious bacteria have recently been uncovered. Studies on nematode immunity can be instructive in exploring innate immune signaling in the absence of specialized immune cells and adaptive immunity. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ermolaeva, Maria A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433492
DOI:	10.1016/j.smim.2014.04.005
Journal or Publication Title:	Semin. Immunol.
Volume:	26
Number:	4
Page Range:	S. 303 - 310
Date:	2014
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1096-3618
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TISSUE-SPECIFIC ACTIVITIES; PROTEIN RESPONSE GENES; CAENORHABDITIS-ELEGANS; LIFE-SPAN; SIGNALING PATHWAY; DNA-DAMAGE; STRESS RESISTANCE; VIRULENCE FACTORS; RNA INTERFERENCE; FACTOR SKN-1 Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43349