Universität zu Köln

Eckes, Beate, Krieg, Thomas and Wickstroem, Sara A. (2014). Role of integrin signalling through integrin-linked kinase in skin physiology and pathology. Exp. Dermatol., 23 (7). S. 453 - 457. HOBOKEN: WILEY. ISSN 1600-0625

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Abstract

Cell-matrix adhesions provide structural stability to the tissue and regulate intracellular signalling pathways that are important for cell fate decisions of the different cell populations within the skin. As a consequence of these central functions, genetic or functional impairment of various key protein components of matrix adhesions plays a causative role in the aetiology or pathophysiology in a large variety of skin disorders. Research towards understanding the molecular composition of these adhesions as well as the mechanisms by which they transmit signals is therefore of obvious importance. In this essay, we discuss the roles of integrin-linked kinase, a key component of cell-matrix adhesions, in the (patho)physiology of skin and in particular highlight its role in regulating mechanical tension and matrix remodelling both in the epidermis and in the dermis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eckes, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Krieg, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wickstroem, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-434423
DOI:	10.1111/exd.12429
Journal or Publication Title:	Exp. Dermatol.
Volume:	23
Number:	7
Page Range:	S. 453 - 457
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0625
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ILK; ADHESION; GROWTH; BETA-1-INTEGRIN; MORPHOGENESIS; MECHANISMS; TGF-BETA-1; MIGRATION; ABLATION; BIOLOGY Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43442