Universität zu Köln

Geikowski, Tilman, Becker, Ingrid ORCID: 0000-0001-5829-3553 and Horneff, Gerd (2014). Predictors of response to etanercept in polyarticular-course juvenile idiopathic arthritis. RHEUMATOLOGY, 53 (7). S. 1245 - 1250. OXFORD: OXFORD UNIV PRESS. ISSN 1462-0332

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Abstract

Methods. A total of 863 patients registered in the BIKER registry were included. Predictors of response for ACR paediatric criteria (PedACR) 30, 70 and 90 were analysed by bivariate analysis and logistic regression. Results. After 6 months, 81.9% of the included patients fulfilled the PedACR30, 55.2% the PedACR70 and 31.3% the PedACR90 criteria. In bivariate analyses, factors positively correlated with a PedACR70/90 response were extended oligoarthritis JIA category, lower age at the start of treatment, shorter disease duration until treatment start, no concomitant use of corticosteroids, duration of morning stiffness, parents' global assessment of overall well-being, lower Childhood Health Assessment Questionnaire (CHAQ) and higher ESR and ANA. Correlation between the JIA category systemic arthritis and response was significantly negative. Predictive factors for PedACR70 in multivariate logistic regression analysis were CHAQ [odds ratio (OR) = 0.70], ESR (OR = 1.02) and concomitant treatment with corticosteroids (OR = 0.68). Age at treatment start (OR = 0.94) and the systemic arthritis JIA category (OR = 0.28) were predictive for a PedACR70. We found no sufficiently distinctive models for PedACR30 or 90. Conclusion. Parameters predicting a high-grade response to a 6-month course of etanercept were identifiable and included age at treatment start, disease duration before treatment, JIA category other than systemic arthritis, CHAQ, parents' global assessment and concomitant corticosteroids.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Geikowski, Tilman UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Ingrid UNSPECIFIED orcid.org/0000-0001-5829-3553 UNSPECIFIED Horneff, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-434658
DOI:	10.1093/rheumatology/ket490
Journal or Publication Title:	RHEUMATOLOGY
Volume:	53
Number:	7
Page Range:	S. 1245 - 1250
Date:	2014
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1462-0332
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHILDREN; METHOTREXATE; EFFICACY; SAFETY; THERAPY Multiple languages Rheumatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43465