Universität zu Köln

von Papen, Mitra, Fisse, Mirabell, Sarfeld, Anna-Sophia, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Nowak, Dennis A. (2014). The effects of 1 Hz rTMS preconditioned by tDCS on gait kinematics in Parkinson's disease. J. Neural Transm., 121 (7). S. 743 - 755. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

Hypokinetic gait is a common and very disabling symptom of Parkinson's disease (PD). Repetitive transcranial magnetic stimulation (rTMS) over the motor cortex has been used with variable effectiveness to treat hypokinesia in PD. Preconditioning rTMS by transcranial direct current stimulation (tDCS) may enhance its effectiveness to treat hypokinetic gait in PD. Three-dimensional kinematic gait analysis was performed (1) prior to, (2) immediately after and (3) 30 min after low-frequency rTMS (1 Hz, 900 pulses, 80 % of resting motor threshold) over M1 contralateral to the more affected body side preconditioned by (1) cathodal, (2) anodal or (3) sham tDCS (amperage: 1 mA, duration: 10 min) in ten subjects with PD (7 females, mean age 63 +/- A 9 years) and ten healthy subjects (four females, mean age 50 +/- A 11 years). The effects of tDCS-preconditioned rTMS on gait kinematics were assessed by the following parameters: number of steps, step length, stride length, double support time, cadence, swing and stance phases. Our data suggest a bilateral improvement of hypokinetic gait in PD after 1 Hz rTMS over M1 of the more affected body side preceded by anodal tDCS. In contrast, 1 Hz rTMS alone (preceded by sham tDCS) and 1 Hz rTMS preceded by cathodal tDCS were ineffective to improve gait kinematics in PD. In healthy subjects, gait kinematics was unaffected by either intervention. Preconditioning motor cortex rTMS by tDCS is a promising approach to treat hypokinetic gait in PD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Papen, Mitra UNSPECIFIED UNSPECIFIED UNSPECIFIED Fisse, Mirabell UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarfeld, Anna-Sophia UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Nowak, Dennis A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-434695
DOI:	10.1007/s00702-014-1178-2
Journal or Publication Title:	J. Neural Transm.
Volume:	121
Number:	7
Page Range:	S. 743 - 755
Date:	2014
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1435-1463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; PRIMARY MOTOR CORTEX; FINGER MOVEMENTS; CORTICOMOTOR INHIBITION; CORTICAL EXCITABILITY; REPETITIVE TMS; PERFORMANCE; AREA; IMPROVEMENT; MODULATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43469