Universität zu Köln

Langner, Robert ORCID: 0000-0002-3237-001X, Sternkopf, Melanie A., Kellermann, Tanja S., Grefkes, Christian ORCID: 0000-0002-1656-720X, Kurth, Florian, Schneider, Frank ORCID: 0000-0003-1557-7956, Zilles, Karl ORCID: 0000-0001-9296-9959 and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2014). Translating working memory into action: Behavioral and neural evidence for using motor representations in encoding visuo-spatial sequences. Hum. Brain Mapp., 35 (7). S. 3465 - 3485. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

The neurobiological organization of action-oriented working memory is not well understood. To elucidate the neural correlates of translating visuo-spatial stimulus sequences into delayed (memory-guided) sequential actions, we measured brain activity using functional magnetic resonance imaging while participants encoded sequences of four to seven dots appearing on fingers of a left or right schematic hand. After variable delays, sequences were to be reproduced with the corresponding fingers. Recall became less accurate with longer sequences and was initiated faster after long delays. Across both hands, encoding and recall activated bilateral prefrontal, premotor, superior and inferior parietal regions as well as the basal ganglia, whereas hand-specific activity was found (albeit to a lesser degree during encoding) in contralateral premotor, sensorimotor, and superior parietal cortex. Activation differences after long versus short delays were restricted to motor-related regions, indicating that rehearsal during long delays might have facilitated the conversion of the memorandum into concrete motor programs at recall. Furthermore, basal ganglia activity during encoding selectively predicted correct recall. Taken together, the results suggest that to-be-reproduced visuo-spatial sequences are encoded as prospective action representations (motor intentions), possibly in addition to retrospective sensory codes. Overall, our study supports and extends multi-component models of working memory, highlighting the notion that sensory input can be coded in multiple ways depending on what the memorandum is to be used for. Hum Brain Mapp 35:3465-3484, 2014. (c) 2013 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Langner, Robert UNSPECIFIED orcid.org/0000-0002-3237-001X UNSPECIFIED Sternkopf, Melanie A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kellermann, Tanja S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Kurth, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Frank UNSPECIFIED orcid.org/0000-0003-1557-7956 UNSPECIFIED Zilles, Karl UNSPECIFIED orcid.org/0000-0001-9296-9959 UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-434912
DOI:	10.1002/hbm.22415
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	35
Number:	7
Page Range:	S. 3465 - 3485
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSTERIOR PARIETAL CORTEX; FRONTAL EYE-FIELD; DORSOLATERAL PREFRONTAL CORTEX; POSITRON-EMISSION-TOMOGRAPHY; VENTRAL PREMOTOR CORTEX; BASAL GANGLIA; SPATIAL REPRESENTATIONS; HAND MOVEMENTS; SERIAL ORDER; FUNCTIONAL-ORGANIZATION Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43491