Universität zu Köln

Caisova, Lenka and Melkonian, Michael (2014). Evolution of Helix Formation in the Ribosomal Internal Transcribed Spacer 2 (ITS2) and Its Significance for RNA Secondary Structures. J. Mol. Evol., 78 (6). S. 324 - 338. NEW YORK: SPRINGER. ISSN 1432-1432

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Abstract

Helices are the most common elements of RNA secondary structure. Despite intensive investigations of various types of RNAs, the evolutionary history of the formation of new helices (novel helical structures) remains largely elusive. Here, by studying the nuclear ribosomal Internal Transcribed Spacer 2 (ITS2), a fast-evolving part of the eukaryotic nuclear ribosomal operon, we identify two possible types of helix formation: one type is dichotomous helix formationaEurotransition from one large helix to two smaller helices by invagination of the apical part of a helix, which significantly changes the shape of the original secondary structure but does not increase its complexity (i.e., the total length of the RNA). An alternative type is lateral helix formationaEuroorigin of an extra helical region by the extension of a bulge loop or a spacer in a multi-helix loop of the original helix, which does not disrupt the pre-existing structure but increases RNA size. Moreover, we present examples from the RNA sequence literature indicating that both types of helix formation may have implications for RNA evolution beyond ITS2.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Caisova, Lenka UNSPECIFIED UNSPECIFIED UNSPECIFIED Melkonian, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-436493
DOI:	10.1007/s00239-014-9625-0
Journal or Publication Title:	J. Mol. Evol.
Volume:	78
Number:	6
Page Range:	S. 324 - 338
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1432
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RDNA SEQUENCE COMPARISONS; HIGHER-ORDER STRUCTURE; SACCHAROMYCES-CEREVISIAE; GREEN-ALGAE; PHYLOGENETIC RECONSTRUCTION; HYPERVARIABLE REGIONS; MOLECULAR PHYLOGENY; CONCERTED EVOLUTION; EXPANSION SEGMENTS; SUBSTITUTION RATES Multiple languages Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43649