Universität zu Köln

Koy, A., Timmermann, L. and Pauls, K. A. M. (2014). Deep Brain Stimulation in Secondary Dystonia in Childhood. Klin. Neurophysiol., 45 (2). S. 100 - 106. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4081

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Abstract

Secondary dystonia encompasses a heterogeneous group of diseases with different aetiologies. Cerebral palsy is the most common cause. Pharmacological treatment is often unsatisfactory or side effects are not well tolerated. During the last decade some patients with secondary dystonia were treated with deep brain stimulation (DBS) - with varying results ranging from a good response to no effect. Patients without measurable response in clinical rating scales for dystonia sometimes report improvements in quality of life. The data on paediatric DBS are very limited. According to the experiences with DBS in patients with primary or idiopathic dystonia, DBS at an early stage of disease progression is associated with a greater improvement. Still, the indication for DBS in children has to be considered carefully. In the future, larger prospective studies with young, well-characterised and aetiologically homogeneous cohorts of patients with secondary dystonia are necessary to systematically investigate the effect of DBS on motor function and quality of life to further evaluate the role of DBS in secondary dystonia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koy, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauls, K. A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-436516
DOI:	10.1055/s-0034-1372631
Journal or Publication Title:	Klin. Neurophysiol.
Volume:	45
Number:	2
Page Range:	S. 100 - 106
Date:	2014
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-4081
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLOBUS-PALLIDUS-INTERNUS; PRIMARY GENERALIZED DYSTONIA; DYSKINETIC CEREBRAL-PALSY; FOLLOW-UP; SEGMENTAL DYSTONIA; COMPLICATION RATE; DISEASE DURATION; DYT1 DYSTONIA; CHOREOATHETOSIS; CLASSIFICATION Multiple languages Clinical Neurology; Neuroimaging; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43651