Ammermann, C., Cursiefen, C. and Hermann, M. (2014). Corneal Cross-Linking in Microbial Keratitis to Prevent a chaud Keratoplasty: A Retrospective Case Series. Klinische Monatsblat. Augenheilkunde, 231 (6). S. 619 - 626. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

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Abstract

Background: Corneal cross-linking (CXL) with riboflavin is being used more frequently for the treatment of therapy-resistant microbial keratitis, since increasing drug resistance and specific pathogens, e. g. contact lens-associated Acanthamoeba, make this therapy appear as an attractive option to avoid a keratoplasty chaud. Patients and Methods: This retrospective case series of 11 consecutive patients (4 women, 7 men, aged 24-82 years) who received standardised antimicrobial CXL for therapy-resistant keratitis to avoid a keratoplasty chaud, included 4 cases with detection of bacterial pathogens, one case with proven fungal infection and 6 cases without pathogen detection. Analysed data comprised ophthalmic medical history, general risk factors for microbial keratitis, treatment before and after CXL. The characterisation of the corneal ulcer included photometric measurements of the infiltrates with a median of 16.2 mm(2) and four unmeasurable cases due to extended, not circumscribed lesions. Results: Within the follow-up period (mean 134 +/- standard deviation 82 days), a penetrating keratoplasty was successfully avoided in 6 patients (55%). After CXL 9 patients (82%) received additionally amniotic membrane transplantation. After CXL treatment, topical antibiotic therapy was continued for a mean 27 +/- 13 days postoperatively. Steroids were applied in 91% of the patients. The cornea cleared at least to some extent in 9 patients (82%). Patients with neurotrophic keratopathy or potentially compromised immune system showed no increased failure rate. Conclusion: These results suggest that antimicrobial CXL might be a useful option in patients with therapy-resistant corneal ulcer in order to avoid a perforating keratoplasty chaud. For a comprehensive scientific assessment of this therapy, however, further, ideally prospective randomised interventional studies with large sample sizes are needed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ammermann, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cursiefen, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermann, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-436699
DOI: 10.1055/s-0034-1368535
Journal or Publication Title: Klinische Monatsblat. Augenheilkunde
Volume: 231
Number: 6
Page Range: S. 619 - 626
Date: 2014
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1439-3999
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PHOTODYNAMIC INACTIVATION PDI; AMNIOTIC MEMBRANE TRANSPLANTATION; INFECTIOUS KERATITIS; IN-VITRO; BACTERIAL KERATITIS; RIBOFLAVIN; ULTRAVIOLET; THERAPY; LIGHT; KERATOPATHYMultiple languages
OphthalmologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43669

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