Universität zu Köln

Hentrich, Marcus, Hoffmann, Christian, Mosthaf, Franz, Mueller, Markus, Siehl, Jan, Wyen, Christoph and Hensel, Manfred (2014). Therapy of HIV-associated lymphoma-recommendations of the oncology working group of the German Study Group of Physicians in Private Practice Treating HIV-Infected Patients (DAGNA), in cooperation with the German AIDS Society (DAIG). Ann. Hematol., 93 (6). S. 913 - 922. NEW YORK: SPRINGER. ISSN 1432-0584

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Abstract

AIDS-related aggressive B cell lymphoma (HIV-NHL) is the second most common HIV-associated malignancy. In contrast, Hodgkin-lymphoma (HL) is one of the most common non-AIDS-defining malignancies. Current evidence-based recommendations for the treatment of HIV-associated lymphoma (HIV-lymphoma) are not available. A panel of experts in the field of HIV-related lymphoma performed literature searches of the PubMed, Medline, and Cochrane databases. The consensus process was carried out as an e-mail and meeting-based discussion group. Six cycles of R-CHOP or R-EPOCH are standard of care for patients (pts) with diffuse large B cell lymphoma (DLBCL). Pts with Burkitt lymphoma and good performance status should receive dose-intensive regimens such as the GMALL B-ALL/NHL protocol. Standard therapy has not been defined for pts with plasmablastic and primary effusion lymphoma. Pts with lymphoma in sensitive relapse should receive high-dose chemotherapy followed by autologous stem cell transplantation. Stage- and risk adapted treatment yields high remission and survival rates in pts with HIV-HL similar to those achieved in HIV-negative HL pts. Combination antiretroviral therapy (cART) should be applied concurrently to chemotherapy provided that pharmacokinetic interactions are being considered. Pts with HIV-lymphoma should usually be treated in an identical manner to HIV-negative patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hentrich, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mosthaf, Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Siehl, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wyen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Hensel, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437287
DOI:	10.1007/s00277-014-2058-4
Journal or Publication Title:	Ann. Hematol.
Volume:	93
Number:	6
Page Range:	S. 913 - 922
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0584
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVE ANTIRETROVIRAL THERAPY; NON-HODGKIN-LYMPHOMA; B-CELL LYMPHOMA; NERVOUS-SYSTEM LYMPHOMA; MABTHERA INTERNATIONAL TRIAL; PRIMARY EFFUSION LYMPHOMA; HIGH-DOSE THERAPY; FREE LIGHT-CHAINS; PHASE-II TRIAL; INTENSIVE CHEMOTHERAPY Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43728