Universität zu Köln

Eggers, Carsten, Schwartz, Frank, Pedrosa, David J., Kracht, Lutz and Timmermann, Lars (2014). Parkinson's Disease Subtypes Show a Specific Link between Dopaminergic and Glucose Metabolism in the Striatum. PLoS One, 9 (5). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background: Previous studies have shown different clinical and imaging pattern in tremordominant and akinetic-rigid Parkinson's disease (PD) subtypes. The association between dopaminergic and glucose metabolism has in contrast not been investigated yet. Therefore, this study compared PD subtypes with respect to clinical and imaging findings with the aim of establishing a relationship between clinical subtypes, dopamine and glucose metabolism. Methods: Two groups of a total of 64 idiopathic PD patients (42 male, 22 female, mean age 56 +/- 10.9 years) were analysed: akinetic-rigid (AR, n = 32) and tremor-dominant (TD, n = 32) patients. Both were compared with respect to differential involvement of local striatal dopamine and glucose metabolism using [F-18]-fluoro-L-dopa (F-dopa) and [F-18]-fluorodeoxyglucose (FDG)-PET. Results: The analysis of PD subgroups showed significant differences in the F-dopa uptake in the anterior putamen. Using the results of the local striatal dopamine difference as a volume of interest for the FDG-analysis, analysis of AR patients revealed a significantly lower normalised cerebral metabolic rate of glucose (nCMRGlc) within the ventral striatum. Conclusions: The dual tracer study illlustrates clear differences between TD and AR subtypes in the ventral striatum. In accordance with previous FP-CIT-SPECT studies, it discloses congruent results for the presynaptic dopaminergic system and extends the knowledge about an additional involvement of local metabolic activity in the caudate and anterior putamen. The findings corroborate the specific role of distinct PD subtypes within the cerebello-thalamo-cortical-circuits. Multitracer PET imaging may thus enhance the knowledge about the clinical segregation into subtypes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwartz, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Pedrosa, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kracht, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437812
DOI:	10.1371/journal.pone.0096629
Journal or Publication Title:	PLoS One
Volume:	9
Number:	5
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BASAL GANGLIA; RESTING TREMOR; PROGRESSION; DYSFUNCTION; PET Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43781