Universität zu Köln

Pedrosa, David J., Auth, Michelle, Pauls, K. Amande M., Runge, Matthias, Maarouf, Mohammad, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Timmermann, Lars (2014). Verbal Fluency in Essential Tremor Patients: The Effects of Deep Brain Stimulation. Brain Stimul., 7 (3). S. 359 - 365. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-4754

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Abstract

Objective: To assess the effects of different frequencies of thalamic Deep-Brain-Stimulation (DBS) on cognitive performance of patients suffering from Essential Tremor (ET). Methods: In 17 ET-patients with thalamic-DBS, Tremor-Rating-Scale (TRS), standardized phonemic and semantic verbal fluency (VF), Stroop-Color-Word-Test and Digit-span-test were investigated in three randomized stimulation-settings: i) high-frequency stimulation (HFS), ii) low-frequency stimulation (LFS) and iii) OFF-stimulation (DBS-OFF). Paired-samples t-test for TRS and one-way repeated measures analysis of variance for cognitive performance were calculated. Results: Tremor was reduced during HFS (Mean(TRS-HFS) = 12.9 +/- 9.6) compared to DBS-OFF (Mean(TRS-OFF) 4= 4.4 +/- 19.8, P < .001) and to LFS (Mean(TRS-10Hz) = 50.0 +/- 24.2; P < .001). While performance of Stroop-task and digit-span remained unaffected by stimulation-settings (P > .05), phonemic and semantic VF differed significantly between the three conditions (F-Pvf = 5.28, F-Svf = 3.41, both P < .05). Post-hoc comparisons revealed significant differences for both phonemic and semantic VF between LFS (Mean(Pvf-10Hz) = 54.6 +/- 9.2, Mean(Svf-10Hz) = 56.4 +/- 7.9) and HFS (Mean(Pvf-ON) = 48.3 +/- 11.4, Mean(Svf-ON) = 51.1 +/- 11.0, both P < .05), while DBS-OFF (Mean(Pvf-OFF) = 51.2 +/- 9.3, Mean(Svf-OFF) = 53.6 +/- 12.9) and HFS and DBS-OFF and LFS did not differ significantly (P > .05). Conclusions: HFS compared to LFS or DBS-OFF significantly reduced tremor but simultaneously worsened VF while working memory and cognitive inhibition remained unaffected. In contrast, LFS enhanced VF but did not ameliorate tremor. The data emphasize the relevance of thalamocortical loops for verbal fluency but also suggest that more sophisticated DBS-regimes in ET may improve both motor and cognitive performance. (C) 2014 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pedrosa, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Auth, Michelle UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauls, K. Amande M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Runge, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439878
DOI:	10.1016/j.brs.2014.02.012
Journal or Publication Title:	Brain Stimul.
Volume:	7
Number:	3
Page Range:	S. 359 - 365
Date:	2014
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1876-4754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THALAMIC-STIMULATION; BASAL GANGLIA; CEREBELLAR; MOTOR; MODULATION; COGNITION; DEFICITS; NUCLEUS; MEMORY Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43987