Universität zu Köln

Iannacone, Michelle R., Gheit, Tarik, Pfister, Herbert, Giuliano, Anna R., Messina, Jane L., Fenske, Neil A., Cherpelis, Basil S., Sondak, Vernon K., Roetzheim, Richard G., Silling, Steffi, Pawlita, Michael ORCID: 0000-0002-4720-8306, Tommasino, Massimo and Rollison, Dana E. (2014). Case-Control study of genus-beta human papillomaviruses in plucked eyebrow hairs and cutaneous squamous cell carcinoma. Int. J. Cancer, 134 (9). S. 2231 - 2245. HOBOKEN: WILEY-BLACKWELL. ISSN 1097-0215

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Abstract

Cutaneous human papillomaviruses (HPV) have been reported in cutaneous squamous cell carcinoma (SCC). We conducted a clinic-based case-control study to investigate the association between genus-beta HPV DNA in eyebrow hairs (EBH) and SCC. EBH from 168 SCC cases and 290 controls were genotyped for genus-beta HPV DNA. SCC tumors from a subset of cases (n=142) were also genotyped. Viral load was determined in a subset of specimens positive for a single HPV type. Associations with SCC were estimated by odds ratios (OR) and 95% confidence intervals (CI) adjusted for age and sex using logistic regression. Statistical tests were two-sided. EBH DNA prevalence was greater in cases (87%) than controls (73%) (p<0.05), and the association with SCC increased with the number of HPV types present, (>= 4 types vs. HPV-negative: OR=2.02, 95% CI=1.07-3.80; p(trend)=0.02). Type-specific associations were observed between SCC and DNA in EBH for HPV23 (OR=1.90, 95% CI=1.10-3.30) and HPV38 (OR=1.84, 95% CI=1.04-3.24). Additionally, when compared with the controls, the DNA prevalence in EBH was significantly higher among cases for 11 of the 25 genus-beta types tested, when accounting for DNA for the same HPV type in the tumor (ORs=3.44-76.50). Compared to controls, the mean viral DNA load in EBH among the selected cases was greater for HPV5, HPV8 and HPV24, but lower for HPV38. SCC cases were more likely than controls to have HPV DNA+ EBH for single and multiple HPV types, providing additional support for the potential role of genus-beta HPV infections in SCC development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Iannacone, Michelle R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gheit, Tarik UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Giuliano, Anna R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Messina, Jane L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fenske, Neil A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cherpelis, Basil S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sondak, Vernon K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roetzheim, Richard G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Silling, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Pawlita, Michael UNSPECIFIED orcid.org/0000-0002-4720-8306 UNSPECIFIED Tommasino, Massimo UNSPECIFIED UNSPECIFIED UNSPECIFIED Rollison, Dana E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-440360
DOI:	10.1002/ijc.28552
Journal or Publication Title:	Int. J. Cancer
Volume:	134
Number:	9
Page Range:	S. 2231 - 2245
Date:	2014
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1097-0215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONMELANOMA SKIN CANCERS; MICROARRAY PRIMER EXTENSION; EPIDERMODYSPLASIA-VERRUCIFORMIS; ACTINIC KERATOSES; BETAPAPILLOMAVIRUS INFECTION; DNA LOADS; HPV; PCR; INDIVIDUALS; POPULATION Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44036